Detailed information of TA system TA147663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 162350..163126
• Replicon: chromosome
• Accession: NZ_CP047785
• Organism: Staphylococcus aureus strain UP_1186

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3S99_RS01100
• Protein ID: WP_000031109.1
• Coordinates: 162974..163126 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3S99_RS01095
• Protein ID: WP_001251224.1
• Coordinates: 162350..162949 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S99_RS01075	158266..159723	+	1458	WP_000649917.1	ABC transporter permease subunit	-
E3S99_RS01080	159716..160438	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3S99_RS01085	160589..161716	+	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3S99_RS01090	161721..162191	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3S99_RS01095	162350..162949	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3S99_RS01100	162974..163126	+	153	WP_000031109.1	hypothetical protein	Toxin
E3S99_RS01105	163889..164284	+	396	WP_000901019.1	hypothetical protein	-
E3S99_RS01110	164480..165865	+	1386	WP_000116239.1	class II fumarate hydratase	-
E3S99_RS01115	166322..167143	-	822	WP_160199684.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T147663 WP_000031109.1 NZ_CP047785:162974-163126 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T147663 NZ_CP063198:c239509-239174 [Streptococcus agalactiae CJB111]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147663 WP_001251224.1 NZ_CP047785:162350-162949 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147663 NZ_CP063198:c239786-239499 [Streptococcus agalactiae CJB111]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4