Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2409720..2410243 Replicon chromosome
Accession NZ_CP047784
Organism Staphylococcus aureus strain UP_1209

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag E3T00_RS11850 Protein ID WP_000074049.1
Coordinates 2409720..2409986 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3T00_RS11855 Protein ID WP_000587616.1
Coordinates 2409986..2410243 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T00_RS11830 2405027..2406214 - 1188 WP_000026194.1 MFS transporter -
E3T00_RS11835 2406610..2407386 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
E3T00_RS11840 2407379..2408041 - 663 WP_043044946.1 ATP-binding cassette domain-containing protein -
E3T00_RS11845 2408289..2409365 - 1077 WP_001076671.1 M42 family metallopeptidase -
E3T00_RS11850 2409720..2409986 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
E3T00_RS11855 2409986..2410243 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T00_RS11860 2410602..2411057 + 456 WP_000732076.1 DUF1307 domain-containing protein -
E3T00_RS11865 2411225..2412802 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E3T00_RS11870 2412996..2413745 + 750 WP_043044945.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T147658 WP_000074049.1 NZ_CP047784:c2409986-2409720 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T147658 NZ_CP063169:c2921988-2921722 [Haloactinobacterium sp. RN3S43]
ATGACCTGGGAGGTCCAGTTCGCGCCCAGTGCGGTGCGTGGGCTCGACCGGTTGCCGCCCAGGATTGTCGGCGCCGTCGT
GGAGTTCATCACGGTCACGTTGCCGACGAACCCGGAACGGATGAGCAAGCCGCTCGCCGGTGAGCTGGAGGGGTACCGGT
CCGCTCGTCGCGGCGACTACCGCGTCATTTTCTCGCTCGACGATGCGACATCGGAGTTGCTTGTCATCCGTGTGGCGCAT
CGAGCTGACGTGTACCGGCCCGGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT147658 WP_000587616.1 NZ_CP047784:c2410243-2409986 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT147658 NZ_CP063169:c2922260-2921985 [Haloactinobacterium sp. RN3S43]
ATGAAGACGGTGACGTTGAGCGACGCGAAGGACAAGCTCTCGGGCTACCTCGACGAGGTCGAGACGGAGCACGAGATCGT
CCGCATCACGCGGCACGGGCGCGGTTCTGCCGTGCTCATCAGCCAGGACGATCTCGACTCGCTCCGCGAGACGATCTTCT
GGCTCTCCCAGCCCGGCATCCGGGAGGACATCGCCGAAGCACGGCGGTCGGTCGAGGAGTCGTCGACGATGAGCGCCGAC
GACGTCCGGACGCGGTACGGTCTGCCGCCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References