Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2035700..2036214 Replicon chromosome
Accession NZ_CP047784
Organism Staphylococcus aureus strain UP_1209

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T00_RS09910 Protein ID WP_000581792.1
Coordinates 2035700..2035909 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T00_RS09915 Protein ID WP_000138932.1
Coordinates 2035921..2036214 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T00_RS09890 2031208..2032566 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3T00_RS09895 2032581..2033651 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3T00_RS09900 2033969..2035171 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T00_RS09905 2035435..2035572 - 138 WP_000828354.1 hypothetical protein -
E3T00_RS09910 2035700..2035909 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T00_RS09915 2035921..2036214 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T00_RS09920 2036380..2037864 + 1485 WP_043044026.1 cardiolipin synthase -
E3T00_RS09925 2037892..2038539 + 648 WP_001187630.1 HD domain-containing protein -
E3T00_RS09935 2039153..2040025 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T00_RS09940 2040111..2040752 - 642 WP_043044028.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147652 WP_000581792.1 NZ_CP047784:c2035909-2035700 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147652 NZ_CP063167:c676778-675912 [Variovorax paradoxus]
GTGAGCAAGGACTTGTCGGCCTCCGTGCGAGCGCGCCTGCTCAACATCGCCAAGGCCCAGGGCGTCGACTTCAACCAGGT
GCTGGTGCGCTTCGCCCTGGAACGCATGCTCTACCGCCTTGGCGAGTCGGTGCATGCCGATCGCTTCGTGCTCAAGGGCG
CGCTGCTGTTCACGCTTTGGTACGACATGCCGCACCGCGCGACGCGCGATGCCGATCTGCTCGGTTTCGGTGCCAGCGAT
CTGGCGTCCATGGCCCAGGCCTTCCGTGATATCGCGAGCGTGCGGGTGGACGATGGCATCAGCTTCGATCCGGCTTCGAT
CAGGGTCTCGGAGATTCGCAAAGATGCCGGCTATGCCGGGGCGCGGGTCTTGATCGATGCCGACGTGGCGCGCGCTCGCT
GCAAGACGCAGATCGACGTCGGCTTTGGCGACGCCATCACGCCAGGACCCGCCGATGCGATCTATCCCGTCCTCATCGCC
GATCTGCCGGCGCCTCGCCTTCGCACTTATCCGGCCTATACCGTTGTTTCCGAGAAGCTTCATGCGATCGTCGTGCTGGG
CATGACCAACAGTCGTCTCAAGGACTACCTGGACCTGATGGTCTTGCTGGAGCGCGAGGACCTGGATGACGACATGTTGG
CCAATGCCATTGCCGCGACGTTCATGCGGCGCGGCATGGCGGTGCCAAGGTCGTTGCCGGTGGGCTTGAGCGATGAGTAC
GCAAATGATCCATCCCGACAGGCGCTATGGCACGCGTTCCTCAAGAAAAACGACATGCCATCGCGCCCCTTGGTCGACGT
GGTCGTGCTGCTGCGCGGCCGGCTCGGGCCGGACATGCGAAAAGCTGGATCGCTTCACGCTCCTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147652 WP_000138932.1 NZ_CP047784:c2036214-2035921 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147652 NZ_CP063167:c677380-676775 [Variovorax paradoxus]
GTGCGCCAGGACACCCACGCTCAACGAATTCTCGATCTGCTCCGGCGCAAGGGGATGCTCCGCGCCAGCGATCTGGACGC
CACCAATACGCCCCGTGTGGCGCTGACGCGCATGACGGATGCAGGCCTGCTGGAGAAGGTGGGACGCGGTCTCTACCGCC
TGCCCGAACCGGGAGGCTCCGAACATGAGAGCCTTGCGGCGATCGCCACCAAGGTTCCCCAGGCCGTGTTCTGCCTGCTC
ACCGCCCTGCAGTTCCATGAGCTCACCACGCAGCTGCCGCGCCAGGTCTGGATCGCAATGCCGCGCGGCAGCCATGTCCC
GAGGATCGCCTACCCGCCGCTCAAGATGGTCCAGGTTTCCGGCGAAGCCTATTCGGCGGGCATCGAGGTAGTCGAGCGAG
ACCAGGTGCCACTGCGTGTCTACGGCGTGGCCAAGACCGTGGTGGATTGCTTCAAGCACCGCAACAAGATCGGCCTGGAT
GTGGCGCTCGAAGCCCTTCGAGATGCGCGGGCCCAGCGCAAGGCGTCGGCGGACGAGCTTTGGCACTACGCGAGGATCTG
CCGCGTCGCCAATGTGATGCGTCCCTACCTGGAGGCCATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References