Detailed information of TA system TA147650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1861311..1862087
• Replicon: chromosome
• Accession: NZ_CP047784
• Organism: Staphylococcus aureus strain UP_1209

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: E3T00_RS08925
• Protein ID: WP_000031108.1
• Coordinates: 1861311..1861463 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3T00_RS08930
• Protein ID: WP_001251224.1
• Coordinates: 1861488..1862087 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T00_RS08910	1857174..1857995	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
E3T00_RS08915	1858457..1859842	-	1386	WP_000116236.1	class II fumarate hydratase	-
E3T00_RS08920	1860038..1860433	-	396	WP_000901019.1	hypothetical protein	-
E3T00_RS08925	1861311..1861463	-	153	WP_000031108.1	hypothetical protein	Toxin
E3T00_RS08930	1861488..1862087	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3T00_RS08935	1862246..1862716	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3T00_RS08940	1862721..1863848	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3T00_RS08945	1863999..1864721	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3T00_RS08950	1864714..1866171	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T147650 WP_000031108.1 NZ_CP047784:c1861463-1861311 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T147650 NZ_CP063166:c3390388-3389975 [Variovorax paradoxus]
ATGTACCTGCTCGACACCAACGTCATTTCGGAACTCCGCAAGCCGCGCCCGCACGGCGCGGTCATCGCGTGGCTCACGCC
GATCGCGGACAGCGAGCTGCACCTCTCGGCCGTGACGCTCGGCGAGATCCAGGCCGGGATCGAACTCACGCGCGAGCAGG
ACGCGGCCAAGGCCGACGAGATCGAGCAGTGGGCCGCGCTGGTCGCGGGCTCGTACAACGTCCTGCCGATGGATGCGGAC
ACCTTCAGGCTCTGGGCCAAGCTCATGCATCGCAGCTCCAACACGCTGTACGAAGACGCCATGATCGCGGCCACCGCCAG
GCAGCATTCATTGACCGTGGTGACCCGCAACGTCGCCGACTTCGCGAATTTCGGCGTCGCGCTGCTCAATCCCTTCGAGC
ACGGCAAGCCATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147650 WP_001251224.1 NZ_CP047784:c1862087-1861488 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147650 NZ_CP063166:c3390659-3390402 [Variovorax paradoxus]
ATGAAAAGCTGGCCGGTACAGGACGCCAAGGCGCGTTTCAGCGAGTTCCTCGAAGCCTGTCTGGCCGAGGGGCCCCAGAT
GGTGACGAAACGCGGTGCCGAGGCGGCCGTGCTGGTGCCGGCCGCCGAGTGGCGGCGCTTGCACGCGACGGCTCGTCCTT
CGCTCAAGGAGCTGCTGCTGGCCCCCGAGGCACGCACCGAATTCCTGGTGCCGGAGCGCGGCGCCGCCCGCAGGCGCAAG
GTCACGCCGCTGCGCTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4