Detailed information of TA system TA147647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 826684..827161
• Replicon: chromosome
• Accession: NZ_CP047784
• Organism: Staphylococcus aureus strain UP_1209

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: E3T00_RS03935
• Protein ID: WP_077529198.1
• Coordinates: 826684..826872 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: E3T00_RS03940
• Protein ID: WP_001059690.1
• Coordinates: 826901..827161 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T00_RS03905	822650..823195	+	546	WP_043044654.1	hypothetical protein	-
E3T00_RS03910	823536..824222	+	687	WP_001641381.1	thermonuclease family protein	-
E3T00_RS03915	824579..824779	+	201	WP_001059082.1	cold-shock protein	-
E3T00_RS03920	825275..825493	-	219	WP_000005886.1	hypothetical protein	-
E3T00_RS03925	825555..825839	-	285	WP_001004401.1	hypothetical protein	-
E3T00_RS03930	825927..826496	-	570	WP_001106652.1	hypothetical protein	-
E3T00_RS03935	826684..826872	-	189	WP_077529198.1	hypothetical protein	Toxin
E3T00_RS03940	826901..827161	-	261	WP_001059690.1	hypothetical protein	Antitoxin
E3T00_RS03945	827502..827705	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
E3T00_RS03950	827702..827938	-	237	WP_000368687.1	hypothetical protein	-
E3T00_RS03955	828163..828744	+	582	WP_001140693.1	phosphoglycerate mutase family protein	-
E3T00_RS03960	828817..829434	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
E3T00_RS03965	829589..830083	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
E3T00_RS03970	830482..830904	-	423	WP_043044653.1	organic hydroperoxide resistance protein	-
E3T00_RS03975	831052..831768	+	717	WP_000150016.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-93)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7124.78 Da
• Isoelectric Point: 9.9971

>T147647 WP_077529198.1 NZ_CP047784:c826872-826684 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLIKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T147647 NZ_CP063164:1509260-1509559 [Sulfurovum indicum]
ATGTATGAAGTCAAAATGACAAAGACCTTTTCAAAGTGGTTGAGCAAACTCAAGGATATGAAAGGGCGTATCGCAGTAGC
CCGTCGCATAGAGAGAATGAGTCACGGGAACTTTGGTGATGTCAAATCTGTTGGCACATCTATCTCCGAGCTCAGGATCA
CGACAGGTCCGGGATACAGAGTCTACTTTGCACAAAAAAATGGTCGGATTATCATTTTATTGGTAGGCGGAGACAAGTCT
ACCCAGACAAAAGATATAGAAAAAGCAGAAGCACTGCTAAAGGAGTACAACGATGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT147647 WP_001059690.1 NZ_CP047784:c827161-826901 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT147647 NZ_CP063164:1509552-1509845 [Sulfurovum indicum]
ATGAATAAAGAATTGATCCCTTTTGATCTAGTAGAATATTTGGACAATGAAGAAGCAATGGCAGAATATCTTTCCCAAGT
ACTCGAAGATGGAGATAATGATGAGTTTCTAAGAGCTATAGGGTATCTCGCCAAAGCCAAAGGCATGGCGCAAATTGCCA
AAGAGACAGGCATGGGGAGAGAAAGCCTATATAAGGCGTTTCGTCCCAACGCCAAGCCACGCTTTGATACAGTCATGAAA
GTACTTCATGCTTTGAAGCTCCAGTTGACAGCAGCACCACAGTTGCATCAATAG

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56