Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 812748..813225 Replicon chromosome
Accession NZ_CP047783
Organism Staphylococcus aureus strain UP_1313

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T03_RS03785 Protein ID WP_000052076.1
Coordinates 812748..812936 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T03_RS03790 Protein ID WP_001059690.1
Coordinates 812965..813225 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T03_RS03755 808786..809256 + 471 WP_000824462.1 hypothetical protein -
E3T03_RS03760 809597..810283 + 687 WP_001823812.1 thermonuclease family protein -
E3T03_RS03765 810640..810840 + 201 WP_001059082.1 cold-shock protein -
E3T03_RS03770 811339..811557 - 219 WP_000005888.1 hypothetical protein -
E3T03_RS03775 811619..811903 - 285 WP_001004397.1 hypothetical protein -
E3T03_RS03780 811991..812560 - 570 WP_001106657.1 hypothetical protein -
E3T03_RS03785 812748..812936 - 189 WP_000052076.1 hypothetical protein Toxin
E3T03_RS03790 812965..813225 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3T03_RS03795 813566..813769 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T03_RS03800 813766..814002 - 237 WP_000368687.1 hypothetical protein -
E3T03_RS03805 814226..814807 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
E3T03_RS03810 814880..815497 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
E3T03_RS03815 815653..816147 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
E3T03_RS03820 816546..816968 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3T03_RS03825 817116..817832 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / selk / selq / seb 798594..840503 41909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(10-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147639 WP_000052076.1 NZ_CP047783:c812936-812748 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147639 NZ_CP063156:8365-8625 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGGAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGC
GAGGAAAAAAATGCTAACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147639 WP_001059690.1 NZ_CP047783:c813225-812965 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147639 NZ_CP063156:8615-8866 [Escherichia coli]
ATGCTAACTGAAAACACACCAGAAAACATTAAGCGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References