Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1921462..1921976 Replicon chromosome
Accession NZ_CP047782
Organism Staphylococcus aureus strain UP_1352

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3T04_RS09785 Protein ID WP_000581791.1
Coordinates 1921462..1921671 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3T04_RS09790 Protein ID WP_000138934.1
Coordinates 1921683..1921976 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T04_RS09765 1917351..1918421 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
E3T04_RS09770 1918739..1919941 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T04_RS09775 1920102..1920785 - 684 Protein_1883 transposase -
E3T04_RS09780 1921197..1921334 - 138 WP_000828354.1 hypothetical protein -
E3T04_RS09785 1921462..1921671 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3T04_RS09790 1921683..1921976 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T04_RS09795 1922142..1923626 + 1485 WP_000571560.1 cardiolipin synthase -
E3T04_RS09800 1923654..1924301 + 648 WP_001187612.1 HD domain-containing protein -
E3T04_RS09810 1924458..1924757 + 300 WP_001793952.1 hypothetical protein -
E3T04_RS09815 1924914..1925786 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T04_RS09820 1925872..1926513 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147630 WP_000581791.1 NZ_CP047782:c1921671-1921462 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147630 NZ_CP063153:3796273-3796650 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147630 WP_000138934.1 NZ_CP047782:c1921976-1921683 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147630 NZ_CP063153:3795815-3796183 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References