Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 565310..565787 Replicon chromosome
Accession NZ_CP047782
Organism Staphylococcus aureus strain UP_1352

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T04_RS02840 Protein ID WP_000052076.1
Coordinates 565310..565498 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T04_RS02845 Protein ID WP_001059690.1
Coordinates 565527..565787 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T04_RS02810 561263..561820 + 558 WP_000824491.1 hypothetical protein -
E3T04_RS02815 562161..562847 + 687 WP_001574556.1 thermonuclease family protein -
E3T04_RS02820 563204..563404 + 201 WP_001059082.1 cold-shock protein -
E3T04_RS02825 563901..564119 - 219 WP_000005879.1 hypothetical protein -
E3T04_RS02830 564181..564465 - 285 WP_001004401.1 hypothetical protein -
E3T04_RS02835 564553..565122 - 570 WP_001106663.1 hypothetical protein -
E3T04_RS02840 565310..565498 - 189 WP_000052076.1 hypothetical protein Toxin
E3T04_RS02845 565527..565787 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3T04_RS02850 566128..566331 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T04_RS02855 566328..566564 - 237 WP_000368687.1 hypothetical protein -
E3T04_RS02860 566789..567370 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T04_RS02865 567443..568060 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3T04_RS02870 568216..568710 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T04_RS02875 569109..569531 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3T04_RS02880 569679..570395 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147621 WP_000052076.1 NZ_CP047782:c565498-565310 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147621 NZ_CP063153:c1519143-1518757 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147621 WP_001059690.1 NZ_CP047782:c565787-565527 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147621 NZ_CP063153:c1518767-1518438 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References