Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2859663..2860192 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3T07_RS14350 Protein ID WP_000621176.1
Coordinates 2859830..2860192 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3T07_RS14345 Protein ID WP_000948331.1
Coordinates 2859663..2859833 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS14315 2854699..2855259 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
E3T07_RS14320 2855468..2855947 + 480 WP_001287082.1 hypothetical protein -
E3T07_RS14325 2855940..2857517 + 1578 WP_001294646.1 PH domain-containing protein -
E3T07_RS14330 2857510..2858001 + 492 WP_001286801.1 PH domain-containing protein -
E3T07_RS14335 2858005..2858364 + 360 WP_000581197.1 holo-ACP synthase -
E3T07_RS14340 2858430..2859578 + 1149 WP_001281140.1 alanine racemase -
E3T07_RS14345 2859663..2859833 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3T07_RS14350 2859830..2860192 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3T07_RS14355 2860541..2861542 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3T07_RS14360 2861661..2861987 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3T07_RS14365 2861989..2862468 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3T07_RS14370 2862443..2863213 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T147616 WP_000621176.1 NZ_CP047781:2859830-2860192 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T147616 NZ_CP063153:275178-275351 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147616 WP_000948331.1 NZ_CP047781:2859663-2859833 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147616 NZ_CP063153:274854-275150 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References