147615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2838942..2839456 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3T07_RS14255 Protein ID WP_000581791.1
Coordinates 2839247..2839456 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3T07_RS14250 Protein ID WP_000138934.1
Coordinates 2838942..2839235 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS14220 2834405..2835046 + 642 WP_000483150.1 thiamine phosphate synthase -
E3T07_RS14225 2835132..2836004 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T07_RS14230 2836161..2836460 - 300 WP_001793952.1 hypothetical protein -
E3T07_RS14240 2836617..2837264 - 648 WP_001187612.1 HD domain-containing protein -
E3T07_RS14245 2837292..2838776 - 1485 WP_160191429.1 cardiolipin synthase -
E3T07_RS14250 2838942..2839235 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T07_RS14255 2839247..2839456 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3T07_RS14260 2839584..2839721 + 138 WP_000828354.1 hypothetical protein -
E3T07_RS14265 2840133..2840816 + 684 Protein_2775 transposase -
E3T07_RS14270 2840977..2842179 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T07_RS14275 2842497..2843567 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147615 WP_000581791.1 NZ_CP047781:2839247-2839456 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147615 NZ_CP063151:c2966015-2965665 [Bacillus subtilis subsp. subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
CTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147615 WP_000138934.1 NZ_CP047781:2838942-2839235 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147615 NZ_CP063151:c2966301-2966020 [Bacillus subtilis subsp. subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCATATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References