Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1330464..1330941 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T07_RS06980 Protein ID WP_000052076.1
Coordinates 1330753..1330941 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T07_RS06975 Protein ID WP_001059690.1
Coordinates 1330464..1330724 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS06940 1325856..1326572 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3T07_RS06945 1326720..1327142 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3T07_RS06950 1327541..1328035 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T07_RS06955 1328191..1328808 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3T07_RS06960 1328881..1329462 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T07_RS06965 1329687..1329923 + 237 WP_000368687.1 hypothetical protein -
E3T07_RS06970 1329920..1330123 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T07_RS06975 1330464..1330724 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T07_RS06980 1330753..1330941 + 189 WP_000052076.1 hypothetical protein Toxin
E3T07_RS06985 1331129..1331698 + 570 WP_001106663.1 hypothetical protein -
E3T07_RS06990 1331786..1332070 + 285 WP_001004401.1 hypothetical protein -
E3T07_RS06995 1332132..1332350 + 219 WP_000005879.1 hypothetical protein -
E3T07_RS07000 1332847..1333047 - 201 WP_001059082.1 cold-shock protein -
E3T07_RS07005 1333404..1334090 - 687 WP_001574556.1 thermonuclease family protein -
E3T07_RS07010 1334431..1334988 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / vWbp / clpP 1255268..1363596 108328
- inside Prophage - selk / vWbp / vWbp 1192050..1349018 156968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147607 WP_000052076.1 NZ_CP047781:1330753-1330941 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147607 NZ_CP063149:c124966-124682 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTAGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147607 WP_001059690.1 NZ_CP047781:1330464-1330724 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147607 NZ_CP063149:c125204-124956 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGTACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTCAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCTGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References