Detailed information of TA system TA147607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1330464..1330941
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: E3T07_RS06980
• Protein ID: WP_000052076.1
• Coordinates: 1330753..1330941 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: E3T07_RS06975
• Protein ID: WP_001059690.1
• Coordinates: 1330464..1330724 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS06940	1325856..1326572	-	717	WP_000150036.1	type I 3-dehydroquinate dehydratase	-
E3T07_RS06945	1326720..1327142	+	423	WP_000974455.1	organic hydroperoxide resistance protein	-
E3T07_RS06950	1327541..1328035	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
E3T07_RS06955	1328191..1328808	+	618	WP_000255545.1	LysE/ArgO family amino acid transporter	-
E3T07_RS06960	1328881..1329462	-	582	WP_001140696.1	phosphoglycerate mutase family protein	-
E3T07_RS06965	1329687..1329923	+	237	WP_000368687.1	hypothetical protein	-
E3T07_RS06970	1329920..1330123	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
E3T07_RS06975	1330464..1330724	+	261	WP_001059690.1	hypothetical protein	Antitoxin
E3T07_RS06980	1330753..1330941	+	189	WP_000052076.1	hypothetical protein	Toxin
E3T07_RS06985	1331129..1331698	+	570	WP_001106663.1	hypothetical protein	-
E3T07_RS06990	1331786..1332070	+	285	WP_001004401.1	hypothetical protein	-
E3T07_RS06995	1332132..1332350	+	219	WP_000005879.1	hypothetical protein	-
E3T07_RS07000	1332847..1333047	-	201	WP_001059082.1	cold-shock protein	-
E3T07_RS07005	1333404..1334090	-	687	WP_001574556.1	thermonuclease family protein	-
E3T07_RS07010	1334431..1334988	-	558	WP_000824491.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / vWbp / clpP	1255268..1363596	108328
	-	inside	Prophage	-	selk / vWbp / vWbp	1192050..1349018	156968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T147607 WP_000052076.1 NZ_CP047781:1330753-1330941 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T147607 NZ_CP063149:c124966-124682 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTAGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT147607 WP_001059690.1 NZ_CP047781:1330464-1330724 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT147607 NZ_CP063149:c125204-124956 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGTACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTCAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCTGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56