Detailed information of TA system TA147606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1307353..1308150
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: E3T07_RS06830
• Protein ID: WP_031869171.1
• Coordinates: 1307689..1308150 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: E3T07_RS06825
• Protein ID: WP_001260487.1
• Coordinates: 1307353..1307676 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS06770	1302892..1303113	-	222	WP_001077280.1	DUF2483 family protein	-
E3T07_RS06775	1303123..1303383	-	261	WP_000291090.1	DUF1108 family protein	-
E3T07_RS06780	1303480..1303641	-	162	WP_000066011.1	DUF1270 domain-containing protein	-
E3T07_RS06785	1303634..1303855	-	222	WP_000594789.1	hypothetical protein	-
E3T07_RS06790	1303926..1304156	+	231	WP_000395455.1	hypothetical protein	-
E3T07_RS06795	1304332..1305075	-	744	WP_031844841.1	phage antirepressor KilAC domain-containing protein	-
E3T07_RS06800	1305080..1305262	-	183	Protein_1320	helix-turn-helix transcriptional regulator	-
E3T07_RS06805	1305708..1306190	+	483	WP_000394410.1	hypothetical protein	-
E3T07_RS06810	1306291..1306470	-	180	WP_000438352.1	hypothetical protein	-
E3T07_RS06815	1306485..1306928	-	444	WP_033860313.1	hypothetical protein	-
E3T07_RS06820	1306941..1307189	-	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
E3T07_RS06825	1307353..1307676	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
E3T07_RS06830	1307689..1308150	+	462	WP_031869171.1	toxin	Toxin
E3T07_RS06835	1308334..1309266	+	933	WP_000392183.1	hypothetical protein	-
E3T07_RS06840	1309246..1309425	-	180	WP_000337827.1	hypothetical protein	-
E3T07_RS06845	1309538..1310587	+	1050	WP_031764589.1	site-specific integrase	-
E3T07_RS06850	1310655..1312052	-	1398	WP_001074405.1	Fe-S cluster assembly protein SufB	-
E3T07_RS06855	1312203..1312667	-	465	WP_001010508.1	SUF system NifU family Fe-S cluster assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / vWbp / clpP	1255268..1363596	108328
	-	inside	Prophage	-	selk / vWbp / vWbp	1192050..1349018	156968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18032.42 Da
• Isoelectric Point: 4.7834

>T147606 WP_031869171.1 NZ_CP047781:1307689-1308150 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T147606 NZ_CP063148:61065-61370 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT147606 WP_001260487.1 NZ_CP047781:1307353-1307676 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT147606 NZ_CP063148:60845-61063 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36