Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 94673..95461 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag E3T07_RS00520 Protein ID WP_000525004.1
Coordinates 94673..95134 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag E3T07_RS00525 Protein ID WP_000333630.1
Coordinates 95147..95461 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS00495 90259..90789 + 531 WP_000184383.1 acyl-CoA thioesterase -
E3T07_RS00500 91049..92194 - 1146 WP_001245443.1 radical SAM/CxCxxxxC motif protein YfkAB -
E3T07_RS00505 92239..93285 - 1047 WP_001145722.1 site-specific integrase -
E3T07_RS00510 93398..93577 + 180 WP_000337827.1 hypothetical protein -
E3T07_RS00515 93557..94489 - 933 WP_000392183.1 hypothetical protein -
E3T07_RS00520 94673..95134 - 462 WP_000525004.1 hypothetical protein Toxin
E3T07_RS00525 95147..95461 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
E3T07_RS00530 95613..95849 + 237 WP_001121116.1 helix-turn-helix domain-containing protein -
E3T07_RS00535 95863..96042 + 180 WP_000438352.1 hypothetical protein -
E3T07_RS00540 96143..96625 - 483 WP_000394410.1 hypothetical protein -
E3T07_RS00545 97071..97256 + 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
E3T07_RS00550 97258..97998 + 741 WP_031783118.1 phage antirepressor KilAC domain-containing protein -
E3T07_RS00555 98174..98404 - 231 WP_000395455.1 hypothetical protein -
E3T07_RS00560 98475..98696 + 222 WP_000594789.1 hypothetical protein -
E3T07_RS00565 98689..98850 + 162 WP_000066011.1 DUF1270 domain-containing protein -
E3T07_RS00570 98947..99207 + 261 WP_000291090.1 DUF1108 family protein -
E3T07_RS00575 99217..99438 + 222 WP_001077280.1 DUF2483 family protein -
E3T07_RS00580 99431..100054 + 624 WP_000139720.1 DUF1071 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 92239..135308 43069


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T147596 WP_000525004.1 NZ_CP047781:c95134-94673 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T147596 NZ_CP063147:352986-353333 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT147596 WP_000333630.1 NZ_CP047781:c95461-95147 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT147596 NZ_CP063147:353333-353632 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References