Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 94673..95461 | Replicon | chromosome |
| Accession | NZ_CP047781 | ||
| Organism | Staphylococcus aureus strain UP_1452 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | E3T07_RS00520 | Protein ID | WP_000525004.1 |
| Coordinates | 94673..95134 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | E3T07_RS00525 | Protein ID | WP_000333630.1 |
| Coordinates | 95147..95461 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3T07_RS00495 | 90259..90789 | + | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
| E3T07_RS00500 | 91049..92194 | - | 1146 | WP_001245443.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| E3T07_RS00505 | 92239..93285 | - | 1047 | WP_001145722.1 | site-specific integrase | - |
| E3T07_RS00510 | 93398..93577 | + | 180 | WP_000337827.1 | hypothetical protein | - |
| E3T07_RS00515 | 93557..94489 | - | 933 | WP_000392183.1 | hypothetical protein | - |
| E3T07_RS00520 | 94673..95134 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| E3T07_RS00525 | 95147..95461 | - | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| E3T07_RS00530 | 95613..95849 | + | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| E3T07_RS00535 | 95863..96042 | + | 180 | WP_000438352.1 | hypothetical protein | - |
| E3T07_RS00540 | 96143..96625 | - | 483 | WP_000394410.1 | hypothetical protein | - |
| E3T07_RS00545 | 97071..97256 | + | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| E3T07_RS00550 | 97258..97998 | + | 741 | WP_031783118.1 | phage antirepressor KilAC domain-containing protein | - |
| E3T07_RS00555 | 98174..98404 | - | 231 | WP_000395455.1 | hypothetical protein | - |
| E3T07_RS00560 | 98475..98696 | + | 222 | WP_000594789.1 | hypothetical protein | - |
| E3T07_RS00565 | 98689..98850 | + | 162 | WP_000066011.1 | DUF1270 domain-containing protein | - |
| E3T07_RS00570 | 98947..99207 | + | 261 | WP_000291090.1 | DUF1108 family protein | - |
| E3T07_RS00575 | 99217..99438 | + | 222 | WP_001077280.1 | DUF2483 family protein | - |
| E3T07_RS00580 | 99431..100054 | + | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 92239..135308 | 43069 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T147596 WP_000525004.1 NZ_CP047781:c95134-94673 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T147596 NZ_CP063147:352986-353333 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT147596 WP_000333630.1 NZ_CP047781:c95461-95147 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT147596 NZ_CP063147:353333-353632 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |