Detailed information of TA system TA147589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2350034..2350810
• Replicon: chromosome
• Accession: NZ_CP047780
• Organism: Staphylococcus aureus strain UP_1539

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: E3T11_RS11485
• Protein ID: WP_000031108.1
• Coordinates: 2350658..2350810 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: E3T11_RS11480
• Protein ID: WP_001251224.1
• Coordinates: 2350034..2350633 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T11_RS11460	2345951..2347408	+	1458	WP_000649908.1	ABC transporter permease subunit	-
E3T11_RS11465	2347401..2348123	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3T11_RS11470	2348274..2349401	+	1128	WP_000379985.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3T11_RS11475	2349406..2349876	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3T11_RS11480	2350034..2350633	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
E3T11_RS11485	2350658..2350810	+	153	WP_000031108.1	hypothetical protein	Toxin
E3T11_RS11490	2351937..2352332	+	396	WP_000901021.1	hypothetical protein	-
E3T11_RS11495	2352528..2353913	+	1386	WP_000116224.1	class II fumarate hydratase	-
E3T11_RS11500	2354374..2355195	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T147589 WP_000031108.1 NZ_CP047780:2350658-2350810 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T147589 NZ_CP063143:961181-961393 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT147589 WP_001251224.1 NZ_CP047780:2350034-2350633 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT147589 NZ_CP063143:960875-961168 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4