Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 710899..711376 Replicon chromosome
Accession NZ_CP047780
Organism Staphylococcus aureus strain UP_1539

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T11_RS03355 Protein ID WP_000052076.1
Coordinates 711188..711376 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T11_RS03350 Protein ID WP_001059690.1
Coordinates 710899..711159 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T11_RS03315 706292..707008 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
E3T11_RS03320 707156..707578 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T11_RS03325 707977..708471 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T11_RS03330 708626..709243 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E3T11_RS03335 709316..709897 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T11_RS03340 710122..710358 + 237 WP_000368687.1 hypothetical protein -
E3T11_RS03345 710355..710558 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T11_RS03350 710899..711159 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T11_RS03355 711188..711376 + 189 WP_000052076.1 hypothetical protein Toxin
E3T11_RS03360 711564..712133 + 570 WP_001106652.1 hypothetical protein -
E3T11_RS03365 712221..712505 + 285 WP_001004394.1 hypothetical protein -
E3T11_RS03370 712567..712785 + 219 WP_042909089.1 hypothetical protein -
E3T11_RS03375 713280..713480 - 201 WP_001059082.1 cold-shock protein -
E3T11_RS03380 713837..714523 - 687 WP_001792695.1 thermonuclease family protein -
E3T11_RS03385 714864..715385 - 522 WP_042909090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(53-157)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147578 WP_000052076.1 NZ_CP047780:711188-711376 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147578 NZ_CP063082:c24252-23440 [Helicobacter cinaedi]
ATGTGGGATAGCGATGAGCATCTTAATGATTTTGATAGATTTTTGCTTGAAACTAATCTTGTAGGTGCGACTTCGCTTGA
TGAACTACGCCATAGAGAAAGATTACTTACACTAAAACGCACACAAACACTTAAAACCACACATATTAAACGCGACTTTA
GCTACAAACACCTAAAAGCTATTCATAAACATATATTCCAAGATGTCTATACTTGGGCGGGACAAGATAGGTATGAAATG
GGTTTATATGGATTTATGAGTAAGGGGGATTCTACCTTTTGTAAAGGGAGTTTTCTCCCCAAACAATCTAAAAGTATTTT
TGAGAATCTAAAGCAATGTAGCTTACACGAAAAACAAAGAGATGTGGATACTCTCGCACAGAATTTAACCACCTTTATGG
CTGATTTAAATGCTTTGCACCCTTTTAGAGAGGGCAATGGAAGAGTGCAGAGAATCTTTATCAATGAATTAGCTCATAAT
GCAGGATTTGCGCTAGATTTAAACCTCATACCTAAAAATGATATGATAGAAGCCTCCATACAGGCAATGCAAGGAGATAA
TACAGAGCTTTTAAAGCTTATCAAAACCAACCTATACAGCAACACCCAAGCCAAACTACAAAGACGACTAGATATTAATC
TCAATAACTATGGAAAAGTAAGTGATGAAAAACAAAAACAAGAATTTTTAGAAAGAGCAAACGCTATTAAAGAACAAACT
AAGAAGTTTAATATCACTTTAGATTCCAAGTCTTTGCAGAGATTAGAGAGGATAAATCAAGTGCAGAACAAAGAACGCGG
TAGGGGGAGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147578 WP_001059690.1 NZ_CP047780:710899-711159 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147578 NZ_CP063082:c24520-24257 [Helicobacter cinaedi]
ATGACAGCACAAGTAAATGTATTAGCAACGAATAATTATCCAGAAGCCCATAGCCTAGAAGAATCTTTGGCAATTTTAGA
ATCTTATAGGAACAATCTCACAGAGACACAATATAAAAGCATTCGCTCCAATATTTGCAATTTTGCTATTGAGGATATGT
TTGCAAATCAACAAGATATTATTGAGCTTATTCAAATAGAAAAAGGTGAAAAAACCGCTGATGAAATTATAGCCCAGCAT
AAGAGCCAATGGGGGCTACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References