Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1898019..1898533 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3T12_RS09625 Protein ID WP_000581791.1
Coordinates 1898019..1898228 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3T12_RS09630 Protein ID WP_000138934.1
Coordinates 1898240..1898533 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS09605 1893908..1894978 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
E3T12_RS09610 1895296..1896498 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T12_RS09615 1896659..1897342 - 684 Protein_1851 transposase -
E3T12_RS09620 1897754..1897891 - 138 WP_000828354.1 hypothetical protein -
E3T12_RS09625 1898019..1898228 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3T12_RS09630 1898240..1898533 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T12_RS09635 1898699..1900183 + 1485 WP_000571560.1 cardiolipin synthase -
E3T12_RS09640 1900211..1900858 + 648 WP_001187612.1 HD domain-containing protein -
E3T12_RS09650 1901015..1901314 + 300 WP_001793952.1 hypothetical protein -
E3T12_RS09655 1901471..1902343 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T12_RS09660 1902429..1903070 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1896659..1896835 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147572 WP_000581791.1 NZ_CP047779:c1898228-1898019 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147572 NZ_CP063073:c1486421-1486071 [Pseudomonas poae]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGATTATCTGAGTGACGCGCTCTTCCAGGGTTT
TCAACAGGAGCTGATGAGAAACCCGGAAGCGGGCGATGTCATCGAAGGAACCGGTGGGCTACGCAAGGTTCGCTTCGTTG
ATGAGCGACGCAACAAAGGCAAACGCGGTGGCCTGCGGGTCATTTATTACTGGTGGTCGGGCGGCACGCAATTCTGGCTG
TTCACCCTGTACGGCAAACACGAACAGGACGACCTGGCCCCCCATCACAAAAAAGCCCTGAAACACCTGCTGGACAGGGA
AATCAAAGCGAGAACACAACATGAAACGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147572 WP_000138934.1 NZ_CP047779:c1898533-1898240 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147572 NZ_CP063073:c1486081-1485767 [Pseudomonas poae]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGGCGCCCTGGCCGACGAGCGCCAAGGCAAAGTCACCCTGCG
CACCCACAAGGTCCAGCTCAACAACCTGGCCCCGCTGACCGCCGAAGAGGTGGTGGCCGTGCGCCAACAGCTCAACCTGT
CGCGCTCGGTGTTCGCCATGTACCTGCGCACCAACCTGCGCACCCTGGAAAACTGGGAGCAAGGTCGCGCCAAGCCGAAC
GCCCAGGCCACCACCTTGATTCGCCTGGTGGCGCGGTTTCCGGAAACCGTGGCGCAACTCGCCGCATTAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References