Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1877283..1877812 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3T12_RS09530 Protein ID WP_000621176.1
Coordinates 1877283..1877645 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3T12_RS09535 Protein ID WP_000948331.1
Coordinates 1877642..1877812 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS09510 1874262..1875032 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
E3T12_RS09515 1875007..1875486 - 480 WP_001190825.1 anti-sigma B factor RsbW -
E3T12_RS09520 1875488..1875814 - 327 WP_001052491.1 anti-sigma factor antagonist -
E3T12_RS09525 1875933..1876934 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3T12_RS09530 1877283..1877645 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3T12_RS09535 1877642..1877812 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3T12_RS09540 1877897..1879045 - 1149 WP_001281140.1 alanine racemase -
E3T12_RS09545 1879111..1879470 - 360 WP_000581197.1 holo-ACP synthase -
E3T12_RS09550 1879474..1879965 - 492 WP_001286801.1 PH domain-containing protein -
E3T12_RS09555 1879958..1881535 - 1578 WP_001294646.1 PH domain-containing protein -
E3T12_RS09560 1881528..1882007 - 480 WP_001287082.1 hypothetical protein -
E3T12_RS09565 1882216..1882776 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T147571 WP_000621176.1 NZ_CP047779:c1877645-1877283 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T147571 NZ_CP063071:905543-905890 [Listeria seeligeri]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATACGGCCTGT
CCTCATCATTCAAAATGATATCGGTAATAGGTTCAGTCCAACAGTGATTGTGGCGGCGATAACTGCGAAAATCCAAAAAG
CAAAGTTGCCAACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAAAGAGATTCTGTCATACTTCTAGAACAAATTAGA
ACAATTGATAAACAACGCCTGACAGACAAGATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAACAAGGCGCTGGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT147571 WP_000948331.1 NZ_CP047779:c1877812-1877642 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT147571 NZ_CP063071:905261-905539 [Listeria seeligeri]
GTGTTAGAGAAAGAAAAGCGGATGGTAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTGCAAGAGAAAAGGGCACGTGAGTTAA
GAGACGAGATGGAGCGCGGCTATGCGGAAATGGCGACAATTAACTTTGCTATTGCGTGTGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGACAGGAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References