147566

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1635377..1636153 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E3T12_RS08000 Protein ID WP_000031108.1
Coordinates 1635377..1635529 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag E3T12_RS08005 Protein ID WP_001251219.1
Coordinates 1635554..1636153 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS07985 1631523..1632344 + 822 WP_000669380.1 RluA family pseudouridine synthase -
E3T12_RS07990 1632800..1634185 - 1386 WP_000116227.1 class II fumarate hydratase -
E3T12_RS07995 1634381..1634776 - 396 WP_000901019.1 hypothetical protein -
E3T12_RS08000 1635377..1635529 - 153 WP_000031108.1 hypothetical protein Toxin
E3T12_RS08005 1635554..1636153 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
E3T12_RS08010 1636312..1636782 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E3T12_RS08015 1636787..1637914 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
E3T12_RS08020 1638065..1638787 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E3T12_RS08025 1638780..1640237 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T147566 WP_000031108.1 NZ_CP047779:c1635529-1635377 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T147566 NZ_CP063057:2649816-2651114 [Comamonas thiooxydans]
ATGACGCATGAACTCGAAGTCTGGCTGTTTGATGAGCGCGTCGGCAGTCTGTCGCTGGTGCATGGGCGGCTGAGCTTTGC
CTATGCGACCGACTGGTTGGCGCTGCCGCAGGCCACGGCTTTATCGCAGTCGCTGCCGCTGCAGGCTAAACCTTTTGACG
ATCATCAGACCCGGCCGTTCTTCGCCGGTCTGCTGCCCGAGGGGCAGATGCGGCGCCTGATTGCCCAGCAGTTTCAGGTG
TCGGGCCAAAACGATTTTGCGCTGCTGGACCATATTGGCGGCGAATGCGCGGGGGCCGTGACCTTTCTGGAGCCGGGGCA
GGCCTTGCCGCAGACTAACGGGGCTGGGGCGACCGGGGCACCGGGTGATGTGGAGTGGCTCAGCGATCAAAAGCTGCTCG
CCTTGCTGGACGAGCTGCCGCGTCGCCCCATGCTGGCGGGAGATGACGGGCTGCGGCTATCGCTGGCAGGGGCGCAGGAC
AAGTTGCCCGTGGTGGTGGACGAGAGCATTCCGGGCGCAGTGCGTATCGGTCTGCCGCGTAACGGCGCGCCCAGCTCGCA
TATCTTGAAGCCCGCCATCCATGCGGTGGAGGACAGTGTGGCCAATGAAGGCTTTTGCATGCTGCTGGCCCAGGTCATGG
GGCTGCGGCCTGCCAATGCCCGAATCCAGAGCGTGCTGGGCCGCTCGTTTTTGCTGGTGAAGCGCTATGACCGGGAGCTG
AATGCTCAAGATCTGCACCAGCCGCAGTTGCAACGTCTGCATCAGGAAGACTTTTGCCAGGCGCTGGGCGTGGTGCCCGA
GCTGAAGTACCAGAACGAGGGCGGGCCGGGCCTGGCGCAATGCTTTGCCCTGCTGCGCAGCGTGACCCGGCCCAGCGCGC
CTCAGGTGCTGCGGCTGCTGGATGGGGCGATCTTCAATGCCTTGATTGGCAACCATGATGCCCATGGCAAGAATTTCTCG
CTGCTTTATGGGGGAAGGGCGCCCGTGCTGGCACCGTTCTACGACCTGCTGGCTACAGCGATTTACCCCCAGCTGACGCC
CAAGATGGCAATGAAGATTGGCAGCAAATACAAGTTCAGCGAGCTGGAGGCCAGGCACTGGGAGCAGTTTGCGGAAGAAG
CAGGCCTTGCCAAGGCGGCGACGCGCAAGCGTTTGCAGCAGCTGGCGAACGAACTACCCGCTGCCGCGCGCAAGCTGCAG
GCCGCGCCACCGCATGGTTTTGCGGGCAATGCCGTGGTGACGCAGATCGTGCAGCTGATAGAGCAGCGCTGCGCCTTGAC
GCTGAGGCGCTTGGCCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT147566 WP_001251219.1 NZ_CP047779:c1636153-1635554 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT147566 NZ_CP063057:2649578-2649826 [Comamonas thiooxydans]
ATGTCCACCATCCAAACAACCGAGCAACTGGGCGCGGCCTTGCGCACCGCCCGTAAACAACTGGGGCTGACCCAGCCCCA
GCTTGCCTTGGCCGCAGGCGTGGGCACGCGTTTTATTGTGGATCTCGAGGCTGGCAAGCCCACGGTGCGGCTGGAGCATG
TGCTGCGGGTGATCGATGCGCTGGGCGGGGAGTTGCAGTTGGGCGGCTTGCCGAATACAGCTTCTGAGGGCGCAGACCAT
GACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References