Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 560912..561389 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T12_RS02825 Protein ID WP_000052076.1
Coordinates 560912..561100 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T12_RS02830 Protein ID WP_001059690.1
Coordinates 561129..561389 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS02795 556865..557422 + 558 WP_000824491.1 hypothetical protein -
E3T12_RS02800 557763..558449 + 687 WP_001574556.1 thermonuclease family protein -
E3T12_RS02805 558806..559006 + 201 WP_001059082.1 cold-shock protein -
E3T12_RS02810 559503..559721 - 219 WP_000005879.1 hypothetical protein -
E3T12_RS02815 559783..560067 - 285 WP_001004401.1 hypothetical protein -
E3T12_RS02820 560155..560724 - 570 WP_001106663.1 hypothetical protein -
E3T12_RS02825 560912..561100 - 189 WP_000052076.1 hypothetical protein Toxin
E3T12_RS02830 561129..561389 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3T12_RS02835 561730..561933 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T12_RS02840 561930..562166 - 237 WP_000368687.1 hypothetical protein -
E3T12_RS02845 562391..562972 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T12_RS02850 563045..563662 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3T12_RS02855 563818..564312 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T12_RS02860 564711..565133 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3T12_RS02865 565281..565997 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-90)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147563 WP_000052076.1 NZ_CP047779:c561100-560912 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147563 NZ_CP063056:c2087741-2087382 [Rodentibacter sp. DSM 111151]
ATGACAATTGAAAAAGAATGGGTGGTTATTGCTACCGATCGATTTATCGCTTGGGTAAATGAGCAGGACGAAAGTACAAG
AGAATCTGTATTATCGACTTTAAATATGCTGCGCTTATACGGTCACCACCTATCAAGACCTTATGCAGATACGATAAAAG
GATCTAAATATTCCAATATGAAAGAATTACGTATTCAACATAAAGGAAAACCATTACGTGCATTTTTTGCATTCGATCCA
CTAAGACAAGCCATCGTGCTTTGCGCCGGAGATAAAAGCAACGATAAGAAATTTTATGAACGAATGCTCCGTATCGCAGA
TGATGAATTTTCCGCCTATTTACAAGAATTGGAGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147563 WP_001059690.1 NZ_CP047779:c561389-561129 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147563 NZ_CP063056:c2087380-2087072 [Rodentibacter sp. DSM 111151]
ATGAAAAAATACACCACACTAGACGAACTCATCGCAAGACAATCTCCCGAATCACAACAACGCATTAAAGAAAAAACCGA
AGAGCTTATCTTAGAAGCCGGGCTTTCCGCTTTACGTGAAGACTTAGAGCTTTCTCAAAAAGAACTTGCTGACGCATTGG
GTATTTCCCAACCTGCCGTTGCGCAAATTGAACAGCGTGGCAATGAACTAAAACTTTCTACCTTAAAACGCTATATCGAA
ACAATGGGCGGAAAATTAAGCCTTGCTGTTGAAATGCCAACAGGACATAGCCGAATTTTCCGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References