Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2747545..2748059 Replicon chromosome
Accession NZ_CP047778
Organism Staphylococcus aureus strain UP_1572

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3T13_RS13480 Protein ID WP_000581791.1
Coordinates 2747850..2748059 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3T13_RS13475 Protein ID WP_000138934.1
Coordinates 2747545..2747838 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T13_RS13450 2743008..2743649 + 642 WP_000483150.1 thiamine phosphate synthase -
E3T13_RS13455 2743735..2744607 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T13_RS13465 2745220..2745867 - 648 WP_001187612.1 HD domain-containing protein -
E3T13_RS13470 2745895..2747379 - 1485 WP_000571560.1 cardiolipin synthase -
E3T13_RS13475 2747545..2747838 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T13_RS13480 2747850..2748059 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3T13_RS13485 2748187..2748324 + 138 WP_000828354.1 hypothetical protein -
E3T13_RS13490 2748736..2749419 + 684 Protein_2619 transposase -
E3T13_RS13495 2749580..2750782 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T13_RS13500 2751100..2752170 + 1071 WP_000159639.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T147558 WP_000581791.1 NZ_CP047778:2747850-2748059 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147558 NZ_CP063047:c4460070-4459792 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147558 WP_000138934.1 NZ_CP047778:2747545-2747838 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147558 NZ_CP063047:c4459780-4459475 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References