147549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1240863..1241340 Replicon chromosome
Accession NZ_CP047778
Organism Staphylococcus aureus strain UP_1572

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T13_RS06220 Protein ID WP_000052076.1
Coordinates 1241152..1241340 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T13_RS06215 Protein ID WP_001059690.1
Coordinates 1240863..1241123 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T13_RS06180 1236255..1236971 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3T13_RS06185 1237119..1237541 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3T13_RS06190 1237940..1238434 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T13_RS06195 1238590..1239207 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3T13_RS06200 1239280..1239861 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T13_RS06205 1240086..1240322 + 237 WP_000368687.1 hypothetical protein -
E3T13_RS06210 1240319..1240522 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T13_RS06215 1240863..1241123 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T13_RS06220 1241152..1241340 + 189 WP_000052076.1 hypothetical protein Toxin
E3T13_RS06225 1241528..1242097 + 570 WP_001106663.1 hypothetical protein -
E3T13_RS06230 1242185..1242469 + 285 WP_001004401.1 hypothetical protein -
E3T13_RS06235 1242531..1242749 + 219 WP_000005879.1 hypothetical protein -
E3T13_RS06240 1243246..1243446 - 201 WP_001059082.1 cold-shock protein -
E3T13_RS06245 1243803..1244489 - 687 WP_001574556.1 thermonuclease family protein -
E3T13_RS06250 1244830..1245387 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147549 WP_000052076.1 NZ_CP047778:1241152-1241340 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147549 NZ_CP063046:4323498-4323752 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147549 WP_001059690.1 NZ_CP047778:1240863-1241123 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147549 NZ_CP063046:4323250-4323501 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References