Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1733143..1733940 | Replicon | chromosome |
| Accession | NZ_CP047777 | ||
| Organism | Staphylococcus aureus strain UP_1632 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | E3T16_RS08845 | Protein ID | WP_031807889.1 |
| Coordinates | 1733479..1733940 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | E3T16_RS08840 | Protein ID | WP_001260487.1 |
| Coordinates | 1733143..1733466 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3T16_RS08780 | 1728609..1729775 | - | 1167 | WP_000762534.1 | DUF2800 domain-containing protein | - |
| E3T16_RS08785 | 1729772..1730134 | - | 363 | WP_000985976.1 | hypothetical protein | - |
| E3T16_RS08790 | 1730149..1730472 | - | 324 | WP_000174994.1 | hypothetical protein | - |
| E3T16_RS08795 | 1730551..1730712 | - | 162 | WP_001285963.1 | DUF1270 family protein | - |
| E3T16_RS08800 | 1730725..1730988 | - | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| E3T16_RS08805 | 1731013..1731228 | - | 216 | WP_001036302.1 | hypothetical protein | - |
| E3T16_RS08810 | 1731283..1731648 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| E3T16_RS08815 | 1731617..1731862 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| E3T16_RS08820 | 1731918..1732127 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| E3T16_RS08825 | 1732117..1732260 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| E3T16_RS08830 | 1732275..1732718 | - | 444 | WP_023487065.1 | hypothetical protein | - |
| E3T16_RS08835 | 1732731..1732979 | - | 249 | WP_000272859.1 | helix-turn-helix domain-containing protein | - |
| E3T16_RS08840 | 1733143..1733466 | + | 324 | WP_001260487.1 | helix-turn-helix domain-containing protein | Antitoxin |
| E3T16_RS08845 | 1733479..1733940 | + | 462 | WP_031807889.1 | toxin | Toxin |
| E3T16_RS08850 | 1733958..1734542 | + | 585 | WP_000825948.1 | hypothetical protein | - |
| E3T16_RS08855 | 1734772..1734918 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| E3T16_RS08860 | 1734915..1735529 | - | 615 | WP_000191459.1 | hypothetical protein | - |
| E3T16_RS08865 | 1735655..1736860 | + | 1206 | WP_031795352.1 | site-specific integrase | - |
| E3T16_RS08870 | 1736954..1738888 | - | 1935 | Protein_1702 | YSIRK domain-containing triacylglycerol lipase Lip2/Geh | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | geh | 1691677..1751717 | 60040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18018.35 Da Isoelectric Point: 4.6899
>T147528 WP_031807889.1 NZ_CP047777:1733479-1733940 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKYKEI
Download Length: 462 bp
>T147528 NZ_CP063023:349885-350232 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT147528 WP_001260487.1 NZ_CP047777:1733143-1733466 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT147528 NZ_CP063023:350232-350531 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|