147523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1201219..1201696 Replicon chromosome
Accession NZ_CP047777
Organism Staphylococcus aureus strain UP_1632

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T16_RS06105 Protein ID WP_000052076.1
Coordinates 1201508..1201696 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T16_RS06100 Protein ID WP_001059690.1
Coordinates 1201219..1201479 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T16_RS06065 1196612..1197328 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3T16_RS06070 1197476..1197898 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T16_RS06075 1198297..1198791 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T16_RS06080 1198946..1199563 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3T16_RS06085 1199636..1200217 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3T16_RS06090 1200442..1200678 + 237 WP_000349581.1 hypothetical protein -
E3T16_RS06095 1200675..1200878 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T16_RS06100 1201219..1201479 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T16_RS06105 1201508..1201696 + 189 WP_000052076.1 hypothetical protein Toxin
E3T16_RS06110 1201884..1202453 + 570 WP_001106654.1 hypothetical protein -
E3T16_RS06115 1202541..1202825 + 285 WP_001004399.1 hypothetical protein -
E3T16_RS06120 1202887..1203105 + 219 WP_000005886.1 hypothetical protein -
E3T16_RS06125 1203597..1203797 - 201 WP_001059082.1 cold-shock protein -
E3T16_RS06130 1204154..1204840 - 687 WP_000141557.1 thermonuclease family protein -
E3T16_RS06135 1205181..1205702 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1137356..1223031 85675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147523 WP_000052076.1 NZ_CP047777:1201508-1201696 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147523 NZ_CP063019:c4904366-4904082 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147523 WP_001059690.1 NZ_CP047777:1201219-1201479 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147523 NZ_CP063019:c4904598-4904356 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References