Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1179176..1179964 Replicon chromosome
Accession NZ_CP047777
Organism Staphylococcus aureus strain UP_1632

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag E3T16_RS05960 Protein ID WP_000525004.1
Coordinates 1179503..1179964 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag E3T16_RS05955 Protein ID WP_000333630.1
Coordinates 1179176..1179490 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T16_RS05900 1174332..1174850 - 519 WP_015988663.1 hypothetical protein -
E3T16_RS05905 1174880..1175653 - 774 WP_061713844.1 AAA family ATPase -
E3T16_RS05910 1175653..1176132 - 480 WP_000002516.1 siphovirus Gp157 family protein -
E3T16_RS05915 1176147..1176407 - 261 WP_160177555.1 DUF1108 family protein -
E3T16_RS05920 1176501..1176662 - 162 WP_000066011.1 DUF1270 domain-containing protein -
E3T16_RS05925 1176655..1176876 - 222 WP_000977378.1 hypothetical protein -
E3T16_RS05930 1176890..1177339 - 450 WP_000993183.1 hypothetical protein -
E3T16_RS05935 1177379..1177603 - 225 WP_000187184.1 hypothetical protein -
E3T16_RS05940 1177604..1178383 - 780 WP_148844471.1 phage antirepressor KilAC domain-containing protein -
E3T16_RS05945 1178571..1178774 - 204 WP_000394020.1 hypothetical protein -
E3T16_RS05950 1178788..1179024 - 237 WP_001121116.1 helix-turn-helix domain-containing protein -
E3T16_RS05955 1179176..1179490 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
E3T16_RS05960 1179503..1179964 + 462 WP_000525004.1 hypothetical protein Toxin
E3T16_RS05965 1179982..1180485 + 504 WP_000825944.1 hypothetical protein -
E3T16_RS05970 1180548..1181597 + 1050 WP_001145726.1 site-specific integrase -
E3T16_RS05975 1181665..1183062 - 1398 WP_001074405.1 Fe-S cluster assembly protein SufB -
E3T16_RS05980 1183213..1183677 - 465 WP_001010508.1 SUF system NifU family Fe-S cluster assembly protein -
E3T16_RS05985 1183667..1184917 - 1251 WP_001006450.1 cysteine desulfurase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1137356..1223031 85675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T147522 WP_000525004.1 NZ_CP047777:1179503-1179964 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T147522 NZ_CP063019:c4821422-4821081 [Klebsiella pneumoniae]
ATGAAAACCTTACCTGCAACAATTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACGGTCTGGCAGATGCTGCTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTACCCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATTA
ACGCAGGCATCACACTGGTTGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTGGGCGCAGTGGATATTTTGCGGGCGCGGCAGGCAACCGGCCTGTTACGGCAAAG
ACATCTTCCTTCGATACGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT147522 WP_000333630.1 NZ_CP047777:1179176-1179490 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT147522 NZ_CP063019:c4821772-4821446 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAATTTGGTGACGCCGAATGTCTGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References