Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 76316..77055 Replicon plasmid pEcl1-1
Accession NZ_CP047766
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag GVI62_RS22660 Protein ID WP_013087172.1
Coordinates 76570..77055 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag GVI62_RS22655 Protein ID WP_012540086.1
Coordinates 76316..76582 (+) Length 89 a.a.

Genomic Context

GVI62_RS22615GVI62_RS22620GVI62_RS22625GVI62_RS22655GVI62_RS22660GVI62_RS22665GVI62_RS22630GVI62_RS22635GVI62_RS22640GVI62_RS22645GVI62_RS22650GVI62_RS22670GVI62_RS22675GVI62_RS22680
Location: 71856..72128 (273 bp)
Type: Others
Protein ID: WP_013087154.1
Location: 72172..72537 (366 bp)
Type: Others
Protein ID: WP_013087155.1
Location: 72605..73345 (741 bp)
Type: Others
Protein ID: Protein_84
Location: 76316..76582 (267 bp)
Type: Antitoxin
Protein ID: WP_012540086.1
Location: 76570..77055 (486 bp)
Type: Toxin
Protein ID: WP_013087172.1
Location: 77474..78814 (1341 bp)
Type: Others
Protein ID: WP_000589001.1
Location: 73347..73964 (618 bp)
Type: Others
Protein ID: Protein_85
Location: 73985..74347 (363 bp)
Type: Others
Protein ID: WP_013087168.1
Location: 74423..74968 (546 bp)
Type: Others
Protein ID: WP_013087169.1
Location: 74977..75690 (714 bp)
Type: Others
Protein ID: WP_013087170.1
Location: 75692..76015 (324 bp)
Type: Others
Protein ID: WP_013087171.1
Location: 79070..79492 (423 bp)
Type: Others
Protein ID: WP_032072095.1
Location: 79654..80784 (1131 bp)
Type: Others
Protein ID: WP_004196366.1
Location: 80797..81066 (270 bp)
Type: Others
Protein ID: WP_004196355.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GVI62_RS2261571856..72128+273WP_013087154.1hypothetical protein-
GVI62_RS2262072172..72537+366WP_013087155.1hypothetical protein-
GVI62_RS2262572605..73345+741Protein_84ParB/RepB/Spo0J family partition protein-
GVI62_RS2263073347..73964-618Protein_85TRC40/GET3/ArsA family transport-energizing ATPase-
GVI62_RS2263573985..74347-363WP_013087168.1arsenic metallochaperone ArsD family protein-
GVI62_RS2264074423..74968-546WP_013087169.1sigma-70 family RNA polymerase sigma factor-
GVI62_RS2264574977..75690-714WP_013087170.1arsenical resistance protein ArsH-
GVI62_RS2265075692..76015-324WP_013087171.1metalloregulator ArsR/SmtB family transcription factor-
GVI62_RS2265576316..76582+267WP_012540086.1DUF1778 domain-containing proteinAntitoxin
GVI62_RS2266076570..77055+486WP_013087172.1GNAT family N-acetyltransferaseToxin
GVI62_RS2266577474..78814+1341WP_000589001.1ISNCY family transposase-
GVI62_RS2267079070..79492-423WP_032072095.1nickel resistance OB fold protein NcrY-
GVI62_RS2267579654..80784-1131WP_004196366.1Ni(II)/Co(II) efflux transporter permease subunit NcrC-
GVI62_RS2268080797..81066-270WP_004196355.1nickel-sensing transcriptional repressor NcrB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmiddfrA14 / qnrB1 / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / blaVIM-1 / ant(3'')-Ia / qacE / sul1 / qnrB56-1..178304178304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T147514 WP_013087172.1 NZ_CP047766:76570-77055 [Enterobacter hormaechei]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T147514 NZ_CP063019:332948-333316 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGTCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTATAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT147514 WP_012540086.1 NZ_CP047766:76316-76582 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT147514 NZ_CP063019:332730-332951 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGCTCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5E1AVR5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E1AWX8

References