Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 32135..32772 Replicon plasmid pEcl1-1
Accession NZ_CP047766
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A9E6WXZ4
Locus tag GVI62_RS22360 Protein ID WP_032662169.1
Coordinates 32135..32545 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A9E6WTF5
Locus tag GVI62_RS22365 Protein ID WP_032662167.1
Coordinates 32542..32772 (-) Length 77 a.a.

Genomic Context

GVI62_RS22340GVI62_RS22370GVI62_RS22375GVI62_RS22380GVI62_RS22385GVI62_RS22345GVI62_RS22350GVI62_RS22355GVI62_RS22360GVI62_RS22365GVI62_RS22390
Location: 27501..27851 (351 bp)
Type: Others
Protein ID: WP_032662182.1
Location: 33314..33604 (291 bp)
Type: Others
Protein ID: WP_013087126.1
Location: 33735..34265 (531 bp)
Type: Others
Protein ID: WP_013087127.1
Location: 34284..35060 (777 bp)
Type: Others
Protein ID: WP_015572054.1
Location: 35262..35519 (258 bp)
Type: Others
Protein ID: Protein_36
Location: 28037..28945 (909 bp)
Type: Others
Protein ID: WP_032662179.1
Location: 29492..30514 (1023 bp)
Type: Others
Protein ID: WP_032662174.1
Location: 30499..32061 (1563 bp)
Type: Others
Protein ID: WP_032662171.1
Location: 32135..32545 (411 bp)
Type: Toxin
Protein ID: WP_032662169.1
Location: 32542..32772 (231 bp)
Type: Antitoxin
Protein ID: WP_032662167.1
Location: 35763..36773 (1011 bp)
Type: Others
Protein ID: WP_015572055.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GVI62_RS2234027501..27851+351WP_032662182.1DUF305 domain-containing protein-
GVI62_RS2234528037..28945-909WP_032662179.1HNH endonuclease-
GVI62_RS2235029492..30514-1023WP_032662174.1helicase UvrD-
GVI62_RS2235530499..32061-1563WP_032662171.1AAA family ATPase-
GVI62_RS2236032135..32545-411WP_032662169.1PIN domain-containing proteinToxin
GVI62_RS2236532542..32772-231WP_032662167.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
GVI62_RS2237033314..33604+291WP_013087126.1hypothetical protein-
GVI62_RS2237533735..34265+531WP_013087127.1hypothetical protein-
GVI62_RS2238034284..35060+777WP_015572054.1site-specific integrase-
GVI62_RS2238535262..35519+258Protein_36site-specific integrase-
GVI62_RS2239035763..36773-1011WP_015572055.1RepB family plasmid replication initiator protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmiddfrA14 / qnrB1 / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / blaVIM-1 / ant(3'')-Ia / qacE / sul1 / qnrB56-1..178304178304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14729.03 Da        Isoelectric Point: 5.7351

>T147513 WP_032662169.1 NZ_CP047766:c32545-32135 [Enterobacter hormaechei]
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWAEVSLASQEAGPAAQKLADAFAARLDAILPWDRTAV
DATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR

Download         Length: 411 bp

>T147513 NZ_CP063011:c5333748-5333365 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8645.77 Da        Isoelectric Point: 4.4692

>AT147513 WP_032662167.1 NZ_CP047766:c32772-32542 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRVNL

Download         Length: 231 bp

>AT147513 NZ_CP063011:c5333990-5333748 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References