Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2252427..2253166 Replicon chromosome
Accession NZ_CP047765
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag GVI62_RS10890 Protein ID WP_003857133.1
Coordinates 2252427..2252912 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag GVI62_RS10895 Protein ID WP_045336276.1
Coordinates 2252900..2253166 (-) Length 89 a.a.

Genomic Context

GVI62_RS10860GVI62_RS10865GVI62_RS10870GVI62_RS10875GVI62_RS10880GVI62_RS10885GVI62_RS10905GVI62_RS10890GVI62_RS10895GVI62_RS10900GVI62_RS10910GVI62_RS10915
Location: 2247918..2248490 (573 bp)
Type: Others
Protein ID: WP_045346197.1
Location: 2248493..2249512 (1020 bp)
Type: Others
Protein ID: WP_045346198.1
Location: 2249551..2249928 (378 bp)
Type: Others
Protein ID: WP_023292403.1
Location: 2249965..2250570 (606 bp)
Type: Others
Protein ID: Protein_2120
Location: 2250611..2251306 (696 bp)
Type: Others
Protein ID: WP_045346199.1
Location: 2251322..2252125 (804 bp)
Type: Others
Protein ID: WP_060579890.1
Location: 2254289..2255677 (1389 bp)
Type: Others
Protein ID: WP_045336280.1
Location: 2252427..2252912 (486 bp)
Type: Toxin
Protein ID: WP_003857133.1
Location: 2252900..2253166 (267 bp)
Type: Antitoxin
Protein ID: WP_045336276.1
Location: 2253230..2254159 (930 bp)
Type: Others
Protein ID: WP_060579891.1
Location: 2255699..2256694 (996 bp)
Type: Others
Protein ID: WP_045336282.1
Location: 2256704..2257690 (987 bp)
Type: Others
Protein ID: WP_003857123.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GVI62_RS108602247918..2248490+573WP_045346197.1NAD(P)H-dependent oxidoreductase-
GVI62_RS108652248493..2249512+1020WP_045346198.1aldo/keto reductase-
GVI62_RS108702249551..2249928+378WP_023292403.1DUF1330 domain-containing protein-
GVI62_RS108752249965..2250570+606Protein_2120NAD(P)H-dependent oxidoreductase-
GVI62_RS108802250611..2251306+696WP_045346199.1antibiotic biosynthesis monooxygenase-
GVI62_RS108852251322..2252125+804WP_060579890.1carboxymuconolactone decarboxylase family protein-
GVI62_RS108902252427..2252912-486WP_003857133.1GNAT family N-acetyltransferaseToxin
GVI62_RS108952252900..2253166-267WP_045336276.1DUF1778 domain-containing proteinAntitoxin
GVI62_RS109002253230..2254159-930WP_060579891.1LysR family transcriptional regulator-
GVI62_RS109052254289..2255677+1389WP_045336280.1MFS transporter-
GVI62_RS109102255699..2256694-996WP_045336282.1DUF2891 domain-containing protein-
GVI62_RS109152256704..2257690-987WP_003857123.1DUF979 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T147501 WP_003857133.1 NZ_CP047765:c2252912-2252427 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T147501 NZ_CP063008:c5049783-5048866 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT147501 WP_045336276.1 NZ_CP047765:c2253166-2252900 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT147501 NZ_CP063008:c5050547-5049789 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3L9PBP9

Antitoxin

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Source
ID
Structure
No matching records found

References