Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4965940..4966556 Replicon chromosome
Accession NZ_CP047757
Organism Enterobacter hormaechei strain Eho-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GVI63_RS24095 Protein ID WP_015569913.1
Coordinates 4965940..4966311 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag GVI63_RS24100 Protein ID WP_015569912.1
Coordinates 4966314..4966556 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI63_RS24080 4963440..4964342 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
GVI63_RS24085 4964339..4964974 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
GVI63_RS24090 4964971..4965900 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
GVI63_RS24095 4965940..4966311 - 372 WP_015569913.1 PIN domain-containing protein Toxin
GVI63_RS24100 4966314..4966556 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
GVI63_RS24105 4966755..4967675 + 921 WP_015569911.1 alpha/beta hydrolase -
GVI63_RS24110 4967684..4968625 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
GVI63_RS24115 4968670..4969107 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
GVI63_RS24120 4969104..4969985 - 882 WP_003861949.1 virulence factor BrkB family protein -
GVI63_RS24125 4969979..4970578 - 600 WP_003861947.1 glucose-1-phosphatase -
GVI63_RS24130 4970697..4971497 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T147496 WP_015569913.1 NZ_CP047757:c4966311-4965940 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T147496 NZ_CP063008:2069587-2069689 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT147496 WP_015569912.1 NZ_CP047757:c4966556-4966314 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT147496 NZ_CP063008:c2069696-2069551 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References