Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2840078..2840683 Replicon chromosome
Accession NZ_CP047757
Organism Enterobacter hormaechei strain Eho-2

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag GVI63_RS13605 Protein ID WP_012906750.1
Coordinates 2840078..2840257 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag GVI63_RS13610 Protein ID WP_032619507.1
Coordinates 2840279..2840683 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI63_RS13580 2835407..2836123 + 717 WP_032619512.1 ABC transporter ATP-binding protein -
GVI63_RS13585 2836289..2836759 + 471 WP_017384432.1 hypothetical protein -
GVI63_RS13590 2836765..2837691 - 927 WP_032619511.1 LysR family transcriptional regulator -
GVI63_RS13595 2837721..2838044 - 324 WP_017384434.1 hypothetical protein -
GVI63_RS13600 2838047..2838802 - 756 Protein_2661 DUF4225 domain-containing protein -
GVI63_RS13605 2840078..2840257 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
GVI63_RS13610 2840279..2840683 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GVI63_RS13615 2840724..2841794 - 1071 WP_032635096.1 glycosyltransferase family 9 protein -
GVI63_RS13620 2841871..2842449 - 579 WP_032619505.1 tail fiber assembly protein -
GVI63_RS13625 2842449..2844626 - 2178 WP_058670599.1 phage tail protein -
GVI63_RS13630 2844629..2845180 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 2835419..2943893 108474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T147491 WP_012906750.1 NZ_CP047757:2840078-2840257 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T147491 NZ_CP063004:c20643-20227 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT147491 WP_032619507.1 NZ_CP047757:2840279-2840683 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT147491 NZ_CP063004:c20870-20640 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References