Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3848311..3848968 Replicon chromosome
Accession NZ_CP047740
Organism Enterobacter hormaechei strain Eho-4

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GVI65_RS18600 Protein ID WP_017382887.1
Coordinates 3848311..3848721 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI65_RS18605 Protein ID WP_003863437.1
Coordinates 3848702..3848968 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI65_RS18580 3844309..3846042 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
GVI65_RS18585 3846048..3846761 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI65_RS18590 3846790..3847686 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
GVI65_RS18595 3847788..3848309 + 522 WP_015571793.1 flavodoxin FldB -
GVI65_RS18600 3848311..3848721 - 411 WP_017382887.1 protein YgfX Toxin
GVI65_RS18605 3848702..3848968 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI65_RS18610 3849263..3850243 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
GVI65_RS18615 3850355..3851014 - 660 WP_003863433.1 hemolysin III family protein -
GVI65_RS18620 3851281..3852012 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GVI65_RS18625 3852129..3853562 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T147476 WP_017382887.1 NZ_CP047740:c3848721-3848311 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T147476 NZ_CP062997:c5189029-5188646 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT147476 WP_003863437.1 NZ_CP047740:c3848968-3848702 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT147476 NZ_CP062997:c5189271-5189029 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References