Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2842320..2842925 Replicon chromosome
Accession NZ_CP047740
Organism Enterobacter hormaechei strain Eho-4

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag GVI65_RS13625 Protein ID WP_012906750.1
Coordinates 2842320..2842499 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag GVI65_RS13630 Protein ID WP_032619507.1
Coordinates 2842521..2842925 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI65_RS13600 2837649..2838365 + 717 WP_032619512.1 ABC transporter ATP-binding protein -
GVI65_RS13605 2838531..2839001 + 471 WP_017384432.1 hypothetical protein -
GVI65_RS13610 2839007..2839933 - 927 WP_032619511.1 LysR family transcriptional regulator -
GVI65_RS13615 2839963..2840286 - 324 WP_017384434.1 hypothetical protein -
GVI65_RS13620 2840289..2841044 - 756 Protein_2665 DUF4225 domain-containing protein -
GVI65_RS13625 2842320..2842499 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
GVI65_RS13630 2842521..2842925 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GVI65_RS13635 2842966..2844036 - 1071 WP_032635096.1 glycosyltransferase family 9 protein -
GVI65_RS13640 2844113..2844691 - 579 WP_032619505.1 tail fiber assembly protein -
GVI65_RS13645 2844691..2846868 - 2178 WP_058670599.1 phage tail protein -
GVI65_RS13650 2846871..2847422 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 2837661..2946135 108474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T147473 WP_012906750.1 NZ_CP047740:2842320-2842499 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T147473 NZ_CP062997:c4631100-4630759 [Klebsiella pneumoniae]
ATGAAAACCTTACCTGCAACAACTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACAGTCTGGCAGATGCTACTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTTCTCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCCGGTATTACGCTGGCTGATGCTGTTAACTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTACGGGCGGTAGATATTTTACGGGCTCGGCAGGCAACCGGTCTGCTGCAATATCG
TCGTAACACCTTGTCGCTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT147473 WP_032619507.1 NZ_CP047740:2842521-2842925 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT147473 NZ_CP062997:c4631450-4631124 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAGTTTGTTGATGTTGAATGTCAGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
AAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References