Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2367006..2367745 Replicon chromosome
Accession NZ_CP047740
Organism Enterobacter hormaechei strain Eho-4

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag GVI65_RS11390 Protein ID WP_017382345.1
Coordinates 2367006..2367491 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GVI65_RS11395 Protein ID WP_003857131.1
Coordinates 2367479..2367745 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI65_RS11365 2362582..2363166 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
GVI65_RS11370 2363253..2364011 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
GVI65_RS11375 2364116..2365408 + 1293 WP_023303742.1 hypothetical protein -
GVI65_RS11380 2365408..2366022 + 615 WP_023303743.1 NUDIX hydrolase -
GVI65_RS11385 2366386..2366955 + 570 WP_017382346.1 hypothetical protein -
GVI65_RS11390 2367006..2367491 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
GVI65_RS11395 2367479..2367745 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GVI65_RS11400 2367809..2368738 - 930 WP_023303744.1 LysR family transcriptional regulator -
GVI65_RS11405 2368868..2370256 + 1389 WP_032619651.1 MFS transporter -
GVI65_RS11410 2370278..2371273 - 996 WP_023303746.1 DUF2891 domain-containing protein -
GVI65_RS11415 2371283..2372269 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T147464 WP_017382345.1 NZ_CP047740:c2367491-2367006 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T147464 NZ_CP062997:355041-355388 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT147464 WP_003857131.1 NZ_CP047740:c2367745-2367479 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT147464 NZ_CP062997:355388-355687 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References