Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1105248..1105868 Replicon chromosome
Accession NZ_CP047740
Organism Enterobacter hormaechei strain Eho-4

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GVI65_RS05255 Protein ID WP_015571250.1
Coordinates 1105248..1105466 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GVI65_RS05260 Protein ID WP_006809850.1
Coordinates 1105494..1105868 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI65_RS05225 1101260..1101520 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GVI65_RS05230 1101523..1101663 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GVI65_RS05235 1101660..1102370 - 711 WP_023303201.1 GNAT family N-acetyltransferase -
GVI65_RS05240 1102472..1103932 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
GVI65_RS05245 1103904..1104371 - 468 WP_017383209.1 membrane protein -
GVI65_RS05250 1104488..1105039 - 552 WP_023303203.1 maltose O-acetyltransferase -
GVI65_RS05255 1105248..1105466 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GVI65_RS05260 1105494..1105868 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GVI65_RS05265 1106379..1109525 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
GVI65_RS05270 1109548..1110741 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T147463 WP_015571250.1 NZ_CP047740:c1105466-1105248 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T147463 NZ_CP062997:329069-329437 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT147463 WP_006809850.1 NZ_CP047740:c1105868-1105494 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT147463 NZ_CP062997:328851-329072 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References