Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3835234..3835891 Replicon chromosome
Accession NZ_CP047736
Organism Enterobacter hormaechei strain Eho-5

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GVI66_RS18540 Protein ID WP_017382887.1
Coordinates 3835234..3835644 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI66_RS18545 Protein ID WP_003863437.1
Coordinates 3835625..3835891 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI66_RS18520 3831232..3832965 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
GVI66_RS18525 3832971..3833684 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI66_RS18530 3833713..3834609 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
GVI66_RS18535 3834711..3835232 + 522 WP_015571793.1 flavodoxin FldB -
GVI66_RS18540 3835234..3835644 - 411 WP_017382887.1 protein YgfX Toxin
GVI66_RS18545 3835625..3835891 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI66_RS18550 3836186..3837166 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
GVI66_RS18555 3837278..3837937 - 660 WP_003863433.1 hemolysin III family protein -
GVI66_RS18560 3838204..3838935 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GVI66_RS18565 3839052..3840485 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T147458 WP_017382887.1 NZ_CP047736:c3835644-3835234 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T147458 NZ_CP062986:c4774864-4774580 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT147458 WP_003863437.1 NZ_CP047736:c3835891-3835625 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT147458 NZ_CP062986:c4775096-4774854 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References