Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3633322..3633979 Replicon chromosome
Accession NZ_CP047729
Organism Enterobacter hormaechei strain Eho-6

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1QL73
Locus tag GVI67_RS17295 Protein ID WP_032674037.1
Coordinates 3633322..3633732 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI67_RS17300 Protein ID WP_003863437.1
Coordinates 3633713..3633979 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI67_RS17275 3629320..3631053 - 1734 WP_006811870.1 single-stranded-DNA-specific exonuclease RecJ -
GVI67_RS17280 3631059..3631772 - 714 WP_006811871.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI67_RS17285 3631801..3632697 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GVI67_RS17290 3632799..3633320 + 522 WP_006811872.1 flavodoxin FldB -
GVI67_RS17295 3633322..3633732 - 411 WP_032674037.1 protein YgfX Toxin
GVI67_RS17300 3633713..3633979 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI67_RS17305 3634274..3635254 + 981 WP_006811874.1 tRNA-modifying protein YgfZ -
GVI67_RS17310 3635339..3635998 - 660 WP_006811875.1 hemolysin III family protein -
GVI67_RS17315 3636265..3636996 + 732 WP_006811877.1 MurR/RpiR family transcriptional regulator -
GVI67_RS17320 3637113..3638546 + 1434 WP_006811878.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16292.10 Da        Isoelectric Point: 11.1558

>T147440 WP_032674037.1 NZ_CP047729:c3633732-3633322 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMTGTPWMLNTGMMLRLRRVEDNRREHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T147440 NZ_CP062985:c2227872-2227618 [Escherichia coli UTI89]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT147440 WP_003863437.1 NZ_CP047729:c3633979-3633713 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT147440 NZ_CP062985:c2228120-2227869 [Escherichia coli UTI89]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1QL73

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References