Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2320510..2321255 Replicon chromosome
Accession NZ_CP047729
Organism Enterobacter hormaechei strain Eho-6

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag GVI67_RS11105 Protein ID WP_006810665.1
Coordinates 2320764..2321255 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag GVI67_RS11100 Protein ID WP_032673836.1
Coordinates 2320510..2320776 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI67_RS11080 2315987..2316973 + 987 WP_006810670.1 DUF979 domain-containing protein -
GVI67_RS11085 2316983..2317978 + 996 WP_006810669.1 DUF2891 domain-containing protein -
GVI67_RS11090 2317999..2319387 - 1389 WP_039273807.1 MFS transporter -
GVI67_RS11095 2319516..2320421 + 906 WP_032673837.1 LysR family transcriptional regulator -
GVI67_RS11100 2320510..2320776 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
GVI67_RS11105 2320764..2321255 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
GVI67_RS11110 2321294..2322292 - 999 WP_006810664.1 haloacid dehalogenase-like hydrolase -
GVI67_RS11115 2322289..2323302 - 1014 WP_006810663.1 BatD family protein -
GVI67_RS11120 2323299..2324813 - 1515 WP_006810662.1 VWA domain-containing protein -
GVI67_RS11125 2324810..2325787 - 978 WP_039273812.1 VWA domain-containing protein -
GVI67_RS11130 2325780..2326220 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T147431 WP_006810665.1 NZ_CP047729:2320764-2321255 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T147431 NZ_CP062985:284300-284698 [Escherichia coli UTI89]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT147431 WP_032673836.1 NZ_CP047729:2320510-2320776 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT147431 NZ_CP062985:284004-284297 [Escherichia coli UTI89]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References