Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1117526..1118146 Replicon chromosome
Accession NZ_CP047729
Organism Enterobacter hormaechei strain Eho-6

Toxin (Protein)


Gene name Hha Uniprot ID F5RUW8
Locus tag GVI67_RS05355 Protein ID WP_001291436.1
Coordinates 1117526..1117744 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GVI67_RS05360 Protein ID WP_006809850.1
Coordinates 1117772..1118146 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI67_RS05320 1112751..1113557 - 807 WP_032673625.1 nickel/cobalt efflux protein RcnA -
GVI67_RS05325 1113692..1113964 + 273 WP_006809855.1 metal-sensing transcriptional repressor -
GVI67_RS05330 1113957..1115525 - 1569 WP_006809854.1 EAL domain-containing protein -
GVI67_RS05335 1115743..1116003 + 261 WP_006809853.1 type B 50S ribosomal protein L31 -
GVI67_RS05340 1116006..1116146 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GVI67_RS05345 1116182..1116649 - 468 WP_006809852.1 membrane protein -
GVI67_RS05350 1116766..1117317 - 552 WP_006809851.1 maltose O-acetyltransferase -
GVI67_RS05355 1117526..1117744 - 219 WP_001291436.1 hemolysin expression modulator Hha Toxin
GVI67_RS05360 1117772..1118146 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GVI67_RS05365 1118655..1121801 - 3147 WP_006809849.1 multidrug efflux RND transporter permease subunit -
GVI67_RS05370 1121824..1123017 - 1194 WP_006809848.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T147429 WP_001291436.1 NZ_CP047729:c1117744-1117526 [Enterobacter hormaechei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T147429 NZ_CP062985:c15663-15454 [Escherichia coli UTI89]
ATGCAGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT147429 WP_006809850.1 NZ_CP047729:c1118146-1117772 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT147429 NZ_CP062985:15655-15712 [Escherichia coli UTI89]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VNQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References