Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3120..3721 Replicon plasmid pEclE2-3
Accession NZ_CP047718
Organism Enterobacter hormaechei strain Eho-E2

Toxin (Protein)


Gene name hicA Uniprot ID A0A7T1VMP0
Locus tag GVI74_RS24150 Protein ID WP_045284289.1
Coordinates 3458..3721 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T1QNY9
Locus tag GVI74_RS24145 Protein ID WP_045284288.1
Coordinates 3120..3461 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI74_RS24140 2409..2696 - 288 WP_045284286.1 hypothetical protein -
GVI74_RS24145 3120..3461 - 342 WP_045284288.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GVI74_RS24150 3458..3721 - 264 WP_045284289.1 type II toxin-antitoxin system HicA family toxin Toxin
GVI74_RS24155 3857..4171 - 315 WP_052686900.1 single-stranded DNA-binding protein -
GVI74_RS24160 4267..7122 - 2856 WP_045284290.1 bifunctional DNA primase/polymerase -
GVI74_RS24165 7133..7423 - 291 WP_045289091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..15459 15459
- flank IS/Tn - - 7..1035 1028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-76)

Antitoxin

Uncharacterised protein family HicB

(55-101)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9920.42 Da        Isoelectric Point: 10.6082

>T147426 WP_045284289.1 NZ_CP047718:c3721-3458 [Enterobacter hormaechei]
MTLRKQHQRTLEAIYRRPVSGTIEYKDFKALMLALGAELDESAAGSREGFTLRGEPRVFHRPHPKSTMDKGAVSEARQWL
ERLGIKP

Download         Length: 264 bp

>T147426 NZ_CP062983:c5266165-5265596 [Anaerolinea sp. 'rifampicinis']
ATGAGCTATTATACAGCGCTGCTGGATGCCAATATCCTTTATCCAGCACCTATCCGAGATATGATGGTTCAACTCGCGGT
AGAAGATCTTTTTCGAGCAAAGTGGACGGAAGATATTCATCGGGAATGGATTGAGGCGCTACTTAGAAATGAACCATACC
GTGAACGTGCTGCCTTAGAGCGTACACGCAATTTAATGGATAAAGCGACCCGTGATTCCCTTGTCACGGGTTATAAACCT
CTGATAAATAGTCTTACTTTACCTGATCCTGATGATCGTCATGTCTTGGCCGCAGCTATTGTAGGTCGATGCGACGTTAT
TGTCACACAGAACTTGCACGATTTCCCAGAAAGTGTGGTGAAACCTTATGGTATTGAAATTCAACATCCGGATGACTTCT
TGGCCAATCACCTGAATCTTGCACCAGGGAAGTTTTGTGTCGCGGTTCGCAAGGTACGGGCACGTCTCAAGAATCCACGC
TTCACTGTTCAAGAGTATCTTGCTACATTAACGCGTCAGGGGCTTGTTGTCACGGTTGCCGAACTCGAACAGTATGCTCA
ACTAATTTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12602.23 Da        Isoelectric Point: 5.2005

>AT147426 WP_045284288.1 NZ_CP047718:c3461-3120 [Enterobacter hormaechei]
MINVMKVNGHAATVAFDPEIEMFRGSFVGLTGGADFYARTVEELHREGAESLRFYLEICEKRGIEPYKAYSGKVSTRLTP
ERHQALEQIAAAHGESINQLLNEGADLVIERYA

Download         Length: 342 bp

>AT147426 NZ_CP062983:c5266616-5266167 [Anaerolinea sp. 'rifampicinis']
ATGTTAGCCTACAGACATCGCCCTCCCAATGAAGAAGAATCATCAATTGCTCGTAATTCTAAGCAATTGCTTGCGCAATA
TGCACGAGAAAACGAATCTCTTACAGTTCATGTTACTGACCAGGAAGGCACAATAGAGTTACCTGCTGGAGCTGTCAGTT
TACTGATGGATATATTAGGTGCGATGGCTTCTGGACAAGGTATTACATTGATTCCAGAAAATGCTGAACTAACCACAGTT
CAGGCTGCAGAAGTTCTCAACGTATCGCGTCCATTTCTGATTAAATTGCTTGAGGAAGGCAAAATACCTTACCGAAAGGT
CGGTAAACATCGCCGAATCCTGATGGAAGATGTTATGAATTATAAGCATGCGATTGATGAAGAACGCGAGTCGATTCTGG
ATCAGTTGGTAGCTGATGCGCAGGAGCAGAATATGGGATACGAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VMP0

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1QNY9

References