Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 29166..29809 Replicon plasmid pEclE2-2
Accession NZ_CP047717
Organism Enterobacter hormaechei strain Eho-E2

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag GVI74_RS24100 Protein ID WP_000754566.1
Coordinates 29166..29582 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag GVI74_RS24105 Protein ID WP_001261276.1
Coordinates 29579..29809 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI74_RS24075 24278..25042 + 765 WP_197347221.1 IS6 family transposase -
GVI74_RS24080 25535..26119 - 585 WP_001137892.1 TetR family transcriptional regulator -
GVI74_RS24085 26119..27357 - 1239 WP_000004159.1 MFS transporter -
GVI74_RS24090 27354..28259 - 906 WP_000219391.1 Mph(A) family macrolide 2'-phosphotransferase -
GVI74_RS24095 28381..29085 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
GVI74_RS24100 29166..29582 - 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
GVI74_RS24105 29579..29809 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GVI74_RS24110 30398..30691 + 294 WP_020956883.1 hypothetical protein -
GVI74_RS24115 30755..31441 + 687 WP_020956882.1 hypothetical protein -
GVI74_RS24120 31453..32229 + 777 WP_020956881.1 site-specific integrase -
GVI74_RS24125 32287..32544 - 258 WP_000764642.1 hypothetical protein -
GVI74_RS24130 32673..32777 - 105 WP_032409716.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaVIM-1 / ant(3'')-Ia / qacE / sul1 / mph(A) - 1..33171 33171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T147425 WP_000754566.1 NZ_CP047717:c29582-29166 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T147425 NZ_CP062976:2384229-2384630 [Neisseria sp. ZJ785]
ATACTGCGCTATATGCTCGATACCAATATCTGTATTTACACGATTAAAAACAACCCGGCCGCCGTGCGCGAAAAATTCGG
GCGGCACCAGCATCATCTGTGCATCAGCAGCATTGTGTTGAGCGAGCTGCTTTATGGCGCGGAAAAATCAGCCAATCCCG
AAAAATCATTGGCGATTGTGGAAGGCTTGGCTGCTCGGCTGGAAGTGCAGGATTTTGACGATACCGCTGCCGCGCACGCT
GCCGATATTCGCGCGGCATTGGCAAAAAAAGGCACACCCATCGGGCATTACGATGTGTTGATTGCCGGACACGCGCGCAG
CCGCGGCTTGGTGTTGGTCAGCAATAATATGCGCGAATTTGAGCGTGTGGATGGTTTGCTTTTGGAAAATTGGGCTGAGT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT147425 WP_001261276.1 NZ_CP047717:c29809-29579 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT147425 NZ_CP062976:2384002-2384226 [Neisseria sp. ZJ785]
ATGATGCAAGCCACTATTTTTAAAAGTAATCAGACACAAGCACTACGCTTGCCTAAGGCTGTTGCCTTTCCCGACAACGT
GAAAAAAGTGGATGTGGTAGTGCTCGGCAAAACGCGTCTGCTTACGCCCAGCGAAAATTTGTGGGACGATTGGTTTGCGC
TGCTTGATGCTGCCGATTTCCCCGACCGCGAACCTACTTTTCAAGCCGAACGGGAAAGTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References