Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3878424..3880047 Replicon chromosome
Accession NZ_CP047715
Organism Enterobacter hormaechei strain Eho-E2

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag GVI74_RS18565 Protein ID WP_000088044.1
Coordinates 3878424..3879749 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6M3PBR7
Locus tag GVI74_RS18570 Protein ID WP_012477377.1
Coordinates 3879754..3880047 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI74_RS18535 3874410..3875267 - 858 WP_000784387.1 HNH endonuclease -
GVI74_RS18540 3875283..3875591 - 309 WP_001224686.1 hypothetical protein -
GVI74_RS18545 3876140..3876565 - 426 WP_000278471.1 hypothetical protein -
GVI74_RS18550 3876818..3877633 - 816 WP_001641519.1 HNH endonuclease -
GVI74_RS18555 3877646..3878056 - 411 WP_000985909.1 hypothetical protein -
GVI74_RS18560 3878157..3878363 - 207 WP_000134171.1 hypothetical protein -
GVI74_RS18565 3878424..3879749 - 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
GVI74_RS18570 3879754..3880047 - 294 WP_012477377.1 helix-turn-helix transcriptional regulator Antitoxin
GVI74_RS18575 3880448..3881836 - 1389 WP_000083579.1 hypothetical protein -
GVI74_RS18580 3881841..3882338 - 498 WP_197347214.1 hypothetical protein -
GVI74_RS18585 3882541..3883197 - 657 WP_000462754.1 trypsin-like serine protease -
GVI74_RS18590 3883856..3884248 - 393 WP_000341066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.32 Da        Isoelectric Point: 6.5044

>T147424 WP_000088044.1 NZ_CP047715:c3879749-3878424 [Enterobacter hormaechei]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T147424 NZ_CP062976:1276785-1277063 [Neisseria sp. ZJ785]
ATGGCTTGGAAGGTTGAGTTGCACCGAACGGCAGAAAAAGAATTGGCTAAATTGGACAAACAAGTTGCCGTCAGAATTTT
GAAATTCCTTCACGAACGTGTTGCCGCTTCTGAGAACCCTCGACAAATAGGGGAGGCACTCAAAGGGTCGGCACTTGGCG
AATATTGGAAATACAGGGTAGGGGACTACCGCATTATTACCGAAATCAAAGATAATGTCCTGACGGTTTTGGTATTAAAG
GTCGGCAACCGCCGGGAAATATACCGGTCACGCAACTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10860.30 Da        Isoelectric Point: 10.3134

>AT147424 WP_012477377.1 NZ_CP047715:c3880047-3879754 [Enterobacter hormaechei]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW

Download         Length: 294 bp

>AT147424 NZ_CP062976:1276577-1276801 [Neisseria sp. ZJ785]
ATGATTGCCGTCAGATTGCCTGAGGATATCGAAGCCCGTTTAGCAGAGCTGGCAGCCAAAACCGGCCGCACTAAAACCTT
TTATGTGCGCGAAGCGGTATTAAGCCACTTGGAAGATTTGGAAGATTTATATTTGGCTGAACAGCGATCCATTGAAATCC
AAGCCGGCCGCAGCCAACCTGTTTCATTGGAAGAAGTGATGAAGCGCTATGGCTTGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3PBR7

References