Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3633289..3633946 Replicon chromosome
Accession NZ_CP047715
Organism Enterobacter hormaechei strain Eho-E2

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1QL73
Locus tag GVI74_RS17300 Protein ID WP_032674037.1
Coordinates 3633289..3633699 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI74_RS17305 Protein ID WP_003863437.1
Coordinates 3633680..3633946 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI74_RS17280 3629287..3631020 - 1734 WP_006811870.1 single-stranded-DNA-specific exonuclease RecJ -
GVI74_RS17285 3631026..3631739 - 714 WP_006811871.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI74_RS17290 3631768..3632664 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GVI74_RS17295 3632766..3633287 + 522 WP_006811872.1 flavodoxin FldB -
GVI74_RS17300 3633289..3633699 - 411 WP_032674037.1 protein YgfX Toxin
GVI74_RS17305 3633680..3633946 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI74_RS17310 3634241..3635221 + 981 WP_006811874.1 tRNA-modifying protein YgfZ -
GVI74_RS17315 3635306..3635965 - 660 WP_006811875.1 hemolysin III family protein -
GVI74_RS17320 3636232..3636963 + 732 WP_006811877.1 MurR/RpiR family transcriptional regulator -
GVI74_RS17325 3637080..3638513 + 1434 WP_006811878.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16292.10 Da        Isoelectric Point: 11.1558

>T147423 WP_032674037.1 NZ_CP047715:c3633699-3633289 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMTGTPWMLNTGMMLRLRRVEDNRREHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T147423 NZ_CP062974:251773-252123 [Pontibacillus sp. ALD_SL1]
TTGATCGTAAAAAGAGGCGACGTTTACTTTGCTGACCTTTCCCCGGTCGTTGGCTCAGAACAGGGAGGCGTCCGCCCAGT
CCTCATTCTCCAAAATGATATTGGTAATCGCTTCAGCCCCACTGTTATTGTGGCGGCTATTACTGCGCAAATACAAAAAG
CAAAATTACCCACACACGTAGAAATTGATGCTGAACGATATGGATTTGAGCGGGATTCAGTCATATTGTTAGAGCAAATT
CGAACAATTGATAAGCAAAGACTTACAGACAAAATAACCCATTTAGATGAAGCTATGATGAGCAGGGTTGATGAAGCATT
ACAAATCAGTTTAGGGCTCATTGACTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT147423 WP_003863437.1 NZ_CP047715:c3633946-3633680 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT147423 NZ_CP062974:251493-251768 [Pontibacillus sp. ALD_SL1]
GTGTCCGATAGTTCACAAGAAATTGTAGTGAAATTACCACAGCATTTATTAAAAGAGCTAGATGGTATGGTACAACTCGA
AAATGGTGATCGGAGCGATTTTATTTACCAGGCAACGAAAATGTATTTGCGGGAGCGTAAAAAACGTCATATTCGTGAGT
CGATGCGTCAGGGCTACATGGAAATGGCAAAGATCAATCTAAACATTGCTTCAGAAGCTTTTCAAGCTGAAGAGGAGGCA
GAAACTACCTGCGAACGCTTAGTGAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1QL73

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References