Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2320477..2321222 Replicon chromosome
Accession NZ_CP047715
Organism Enterobacter hormaechei strain Eho-E2

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag GVI74_RS11110 Protein ID WP_006810665.1
Coordinates 2320731..2321222 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag GVI74_RS11105 Protein ID WP_032673836.1
Coordinates 2320477..2320743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI74_RS11085 2315954..2316940 + 987 WP_006810670.1 DUF979 domain-containing protein -
GVI74_RS11090 2316950..2317945 + 996 WP_006810669.1 DUF2891 domain-containing protein -
GVI74_RS11095 2317966..2319354 - 1389 WP_039273807.1 MFS transporter -
GVI74_RS11100 2319483..2320388 + 906 WP_032673837.1 LysR family transcriptional regulator -
GVI74_RS11105 2320477..2320743 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
GVI74_RS11110 2320731..2321222 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
GVI74_RS11115 2321261..2322259 - 999 WP_006810664.1 haloacid dehalogenase-like hydrolase -
GVI74_RS11120 2322256..2323269 - 1014 WP_006810663.1 BatD family protein -
GVI74_RS11125 2323266..2324780 - 1515 WP_006810662.1 VWA domain-containing protein -
GVI74_RS11130 2324777..2325754 - 978 WP_039273812.1 VWA domain-containing protein -
GVI74_RS11135 2325747..2326187 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T147414 WP_006810665.1 NZ_CP047715:2320731-2321222 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T147414 NZ_CP062951:c1416054-1415746 [Bifidobacterium longum subsp. infantis]
GTGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGCCTGCAAGCTCGCAGGCAGGCCATTCGGCGGCATCAAACCCGTGGAAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT147414 WP_032673836.1 NZ_CP047715:2320477-2320743 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT147414 NZ_CP062951:c1415749-1415465 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGTCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References