Detailed information of TA system TA147406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3992055..3992875
• Replicon: chromosome
• Accession: NZ_CP047710
• Organism: Escherichia coli strain Eco-15

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: GVI77_RS19095
• Protein ID: WP_001054379.1
• Coordinates: 3992055..3992312 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: GVI77_RS19100
• Protein ID: WP_000123957.1
• Coordinates: 3992324..3992875 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVI77_RS19065	3987535..3988038	-	504	Protein_3731	DNA helicase	-
GVI77_RS19070	3988124..3988549	+	426	WP_000422741.1	IS66 family insertion sequence hypothetical protein	-
GVI77_RS19075	3988546..3988896	+	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
GVI77_RS19080	3988927..3990540	+	1614	WP_000080195.1	IS66-like element ISEc23 family transposase	-
GVI77_RS19085	3990570..3991301	-	732	Protein_3735	DNA helicase	-
GVI77_RS19090	3991379..3991678	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
GVI77_RS19095	3992055..3992312	+	258	WP_001054379.1	YjhX family toxin	Toxin
GVI77_RS19100	3992324..3992875	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
GVI77_RS19105	3992927..3993673	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
GVI77_RS19110	3993801..3994061	+	261	WP_000077645.1	hypothetical protein	-
GVI77_RS19115	3994099..3994215	+	117	Protein_3741	VOC family protein	-
GVI77_RS19120	3994460..3995581	+	1122	WP_000010833.1	M42 family metallopeptidase	-
GVI77_RS19125	3995578..3995856	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
GVI77_RS19130	3995868..3997181	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	3978542..4001096	22554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T147406 WP_001054379.1 NZ_CP047710:3992055-3992312 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T147406 NZ_CP062948:529227-529505 [Bifidobacterium lemurum]
ATGCGGTTCGCAGATAAACGACTGGAACGATTTTGGGAATCGGGAATCATCCCATCCCAATATCCGCAAGGCGTGGCACG
AACGCTGATGAGAAAACTGCAGATGCTTGACGCTGCTGAGTACCCCCAAGCGTTACGGACCCCGCCTGGCAACCGTTTCG
AGGAGTTATCCGGAGACCTGGCCAGCCATTACAGCGTCCGCGTCAATAGGCAATGGCGGCTGGTGTTTCGATGGGACAGG
AAGGAGGCCACCGATGTTCGATTCGTCGACTACCACTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT147406 WP_000123957.1 NZ_CP047710:3992324-3992875 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT147406 NZ_CP062948:529597-529884 [Bifidobacterium lemurum]
ATGACGGACTTGCTCTCCACCCCGGGAGAGATTCTCGAAGAGGAGTTTCTTTCGCCACTGGGCATCTCTCATTACCGATT
AGCCAAATCCATCGGCGTATCGCAGTCCGCGATCAGCGACATCATTCATGGGCGTCGCGCGATCACCGCACGCATGTCGC
TGCTGCTGGGCATGGCATTGGGAACCGGACCTCATTTCTGGATGAATCTGCAATCCACGTATGACTTGAAAAAGGCCGAA
GCCGAAGGCATTCCAACCATCGAACCCCTGATACGTAAAAACGCCTGA

Structures

Toxin

• AlphaFold DB: B6I030