147400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2369801..2371389 Replicon chromosome
Accession NZ_CP047710
Organism Escherichia coli strain Eco-15

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag GVI77_RS11255 Protein ID WP_001125411.1
Coordinates 2370067..2371389 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag GVI77_RS11250 Protein ID WP_001296076.1
Coordinates 2369801..2370067 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI77_RS11235 2366169..2367620 + 1452 WP_000854638.1 tagaturonate reductase -
GVI77_RS11240 2367817..2368731 + 915 WP_001296077.1 bestrophin family protein -
GVI77_RS11245 2368735..2369493 - 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
GVI77_RS11250 2369801..2370067 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GVI77_RS11255 2370067..2371389 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
GVI77_RS11260 2372299..2372862 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
GVI77_RS11265 2373224..2373934 + 711 WP_001195177.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T147400 WP_001125411.1 NZ_CP047710:2370067-2371389 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

>T147400 NZ_CP062946:2331679-2331960 [Thalassotalea sp. LPB0316]
GTGCTAAAGATTAGAACGAAGAGTTCTTTTAAAAAGGATTTGAAACGAGCTGCTAAGAATAATCGGCATAACACTAAACT
ATTAAAAGAGTTAATAGATAAGCATCTAATTATAACAGGAACAGTACCAAGTCAATACAAACCACACCTGTTGCAAGGTA
ATTGGCAGCCTCACATGGAGTGTCATATTCAACCTGACTTTTTACTGATATGGGATGTTGATTGGGAAGCCGAGGAATTG
ATCTTAGTGCGCTGTGGCTCTCACTCTGAACTGTTTGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT147400 WP_001296076.1 NZ_CP047710:2369801-2370067 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT147400 NZ_CP062946:2331426-2331692 [Thalassotalea sp. LPB0316]
ATGAAAACTGAAATGGTTAGAGCTAGAGTTTCTAGTGAGTTAAAACACGAATCTGAAGCTATTCTTTCGGAGTTAGGTAT
GAGTATGTCTGATGCTATCCGAATCTTTTTAAGTCAAGTCAAGTTGCGCCATGAATTTCCAGTTGAATTAAAAGTGCCTA
ATCAAGACACTTTAAAGGCGATGGAGGCGCCTGTTACTGAAGATGTTTATGATTCTACTGACGATTTATTTAACGATATT
CTAGGCAGTAGCAGTGCTAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References