Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786620..787277 Replicon chromosome
Accession NZ_CP047707
Organism Klebsiella pneumoniae strain Kpn-13

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GVI78_RS03910 Protein ID WP_002916310.1
Coordinates 786867..787277 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GVI78_RS03905 Protein ID WP_002916312.1
Coordinates 786620..786886 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI78_RS03880 781776..783209 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GVI78_RS03885 783328..784056 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GVI78_RS03890 784106..784417 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GVI78_RS03895 784581..785240 + 660 WP_002916317.1 hemolysin III family protein -
GVI78_RS03900 785391..786374 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
GVI78_RS03905 786620..786886 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GVI78_RS03910 786867..787277 + 411 WP_002916310.1 protein YgfX Toxin
GVI78_RS03915 787284..787805 - 522 WP_004144730.1 flavodoxin FldB -
GVI78_RS03920 787906..788802 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GVI78_RS03925 788825..789538 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI78_RS03930 789544..791277 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T147367 WP_002916310.1 NZ_CP047707:786867-787277 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T147367 NZ_CP062916:1850464-1850817 [Raoultella terrigena]
GTGTGGATAATTAAGACGACGGATCGGTTTGACGGCTGGTTTAGTACGCTTTGCGCAACCGATCGGGCATGTGTACTGGC
ATTGCTACTGGTTCTGCGGGAAAGAGGGCCGGGCTTGTCCAGACCTTATGCCGATACGCTCAAAGGCTCATGCTACGGTA
ATATGAAAGAGCTGCGCGTTCAGAGCCGGGGCGATCCCATCCGGGTGTTTTTCGCCTTCGACCCATTCCGGGCTGGCATC
CTGCTCTGCGCGGGTCACAAGGTCGGTAATGAAAAACGCTTCTATGAGCAGACGATCCCAATTGCCGACCGGGAATTCAC
AGATTATTTGAATACGTTAGATGATAAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT147367 WP_002916312.1 NZ_CP047707:786620-786886 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT147367 NZ_CP062916:1850822-1851124 [Raoultella terrigena]
ATGGGCAGAACGCTCGAACAGCTTCTTGCGGATGAGAAACCGGAGGTGGTGGCCGACGCGCAGGCGATGGCGACGGACAT
CCTGCTCAACATCCATCTTGCCGAACTGCGTGAAAAGGTGCAGAAAACGCAGGTAGAAATGGCGCAGGCCCTGGGCATCC
GGCAGCCTACCGTCGCCAGCATGGAAAAGCAGGGGCGCGATTTGAAACTCTCCACCCTTAAGCGTTACGTTGAGGCGGCA
GGCGGTAAACTGCGTCTTGATGTGGAGCTGCCTGACGGCTCTCACTTCGGCTTTGCTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References