147363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 20484..21006 Replicon plasmid pKpn14-1
Accession NZ_CP047701
Organism Klebsiella pneumoniae strain Kpn-14

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag GVI79_RS26590 Protein ID WP_004181778.1
Coordinates 20722..21006 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag GVI79_RS26585 Protein ID WP_025368601.1
Coordinates 20484..20732 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI79_RS26565 15693..16514 - 822 WP_004026535.1 hypothetical protein -
GVI79_RS26570 16576..16929 - 354 WP_004181774.1 hypothetical protein -
GVI79_RS26575 17074..18060 - 987 WP_025368599.1 hypothetical protein -
GVI79_RS26580 18394..20193 - 1800 WP_025368600.1 ATP-dependent helicase -
GVI79_RS26585 20484..20732 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GVI79_RS26590 20722..21006 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GVI79_RS26595 21236..22462 + 1227 WP_025368602.1 transposase -
GVI79_RS26600 22748..23173 - 426 WP_040120489.1 IS200/IS605 family transposase -
GVI79_RS26605 23210..24436 + 1227 WP_025368604.1 transposase -
GVI79_RS26610 24502..25628 - 1127 Protein_29 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-1 / tet(B) / sul1 / qacE / ant(3'')-Ia / aph(3')-Ia / aac(3)-IIa / blaTEM-1B iucA / iucB / iucC / iucD / iutA / rmpA2 1..279435 279435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T147363 WP_004181778.1 NZ_CP047701:20722-21006 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T147363 NZ_CP062915:c39190-39008 [Escherichia coli O112ab:H8]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT147363 WP_025368601.1 NZ_CP047701:20484-20732 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT147363 NZ_CP062915:c39384-39187 [Escherichia coli O112ab:H8]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References