Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4799410..4799926 Replicon chromosome
Accession NZ_CP047700
Organism Klebsiella pneumoniae strain Kpn-14

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GVI79_RS23805 Protein ID WP_002886902.1
Coordinates 4799410..4799694 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GVI79_RS23810 Protein ID WP_002886901.1
Coordinates 4799684..4799926 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI79_RS23780 4794826..4795134 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
GVI79_RS23785 4795219..4795392 + 174 WP_032408826.1 hypothetical protein -
GVI79_RS23790 4795395..4796138 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GVI79_RS23795 4796495..4798633 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GVI79_RS23800 4798942..4799406 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GVI79_RS23805 4799410..4799694 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GVI79_RS23810 4799684..4799926 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GVI79_RS23815 4800004..4801914 - 1911 WP_062921034.1 BglG family transcription antiterminator -
GVI79_RS23820 4801937..4803091 - 1155 WP_002886900.1 lactonase family protein -
GVI79_RS23825 4803158..4803898 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T147361 WP_002886902.1 NZ_CP047700:c4799694-4799410 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T147361 NZ_CP062913:60568-60720 [Escherichia coli O112ab:H8]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT147361 WP_002886901.1 NZ_CP047700:c4799926-4799684 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT147361 NZ_CP062913:c60513-60456 [Escherichia coli O112ab:H8]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References