Detailed information of TA system TA147357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2625593..2627181
• Replicon: chromosome
• Accession: NZ_CP047700
• Organism: Klebsiella pneumoniae strain Kpn-14

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GVI79_RS13070
• Protein ID: WP_004213069.1
• Coordinates: 2625593..2626915 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GVI79_RS13075
• Protein ID: WP_004176198.1
• Coordinates: 2626915..2627181 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVI79_RS13055	2620649..2623150	+	2502	WP_004213067.1	fimbrial biogenesis outer membrane usher protein	-
GVI79_RS13060	2623138..2624142	+	1005	WP_004213068.1	type 1 fimbrial protein	-
GVI79_RS13065	2624284..2625576	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
GVI79_RS13070	2625593..2626915	-	1323	WP_004213069.1	type II toxin-antitoxin system HipA family toxin	Toxin
GVI79_RS13075	2626915..2627181	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GVI79_RS13080	2627567..2627893	-	327	WP_197348513.1	hydroxyisourate hydrolase	-
GVI79_RS13085	2627890..2628390	-	501	WP_004215086.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GVI79_RS13090	2628368..2629747	-	1380	WP_004215088.1	purine permease	-
GVI79_RS13095	2630093..2631247	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
GVI79_RS13100	2631228..2632151	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49128.44 Da
• Isoelectric Point: 7.5357

>T147357 WP_004213069.1 NZ_CP047700:c2626915-2625593 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T147357 NZ_CP062910:4115308-4115715 [Escherichia coli O112ab:H8]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT147357 WP_004176198.1 NZ_CP047700:c2627181-2626915 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT147357 NZ_CP062910:4115061-4115327 [Escherichia coli O112ab:H8]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA