Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807195..807852 Replicon chromosome
Accession NZ_CP047700
Organism Klebsiella pneumoniae strain Kpn-14

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GVI79_RS04070 Protein ID WP_002916310.1
Coordinates 807442..807852 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GVI79_RS04065 Protein ID WP_002916312.1
Coordinates 807195..807461 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI79_RS04040 802351..803784 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
GVI79_RS04045 803903..804631 - 729 WP_062920457.1 MurR/RpiR family transcriptional regulator -
GVI79_RS04050 804681..804992 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GVI79_RS04055 805156..805815 + 660 WP_002916317.1 hemolysin III family protein -
GVI79_RS04060 805966..806949 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GVI79_RS04065 807195..807461 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GVI79_RS04070 807442..807852 + 411 WP_002916310.1 protein YgfX Toxin
GVI79_RS04075 807859..808380 - 522 WP_004144730.1 flavodoxin FldB -
GVI79_RS04080 808481..809377 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GVI79_RS04085 809400..810113 + 714 WP_062920458.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI79_RS04090 810119..811852 + 1734 WP_062920459.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T147348 WP_002916310.1 NZ_CP047700:807442-807852 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T147348 NZ_CP062910:1045470-1045577 [Escherichia coli O112ab:H8]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT147348 WP_002916312.1 NZ_CP047700:807195-807461 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT147348 NZ_CP062910:c1045420-1045357 [Escherichia coli O112ab:H8]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References