Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yxiD-yxxD/-
Location 1966782..1967809 Replicon chromosome
Accession NZ_CP047699
Organism Priestia megaterium strain 5-3

Toxin (Protein)


Gene name yxiD Uniprot ID -
Locus tag GVI46_RS09655 Protein ID WP_081252134.1
Coordinates 1966782..1967375 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name yxxD Uniprot ID -
Locus tag GVI46_RS09660 Protein ID WP_053487199.1
Coordinates 1967381..1967809 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI46_RS09640 1962626..1962976 + 351 WP_013056623.1 metalloregulator ArsR/SmtB family transcription factor -
GVI46_RS09645 1962992..1964290 + 1299 WP_016763796.1 arsenical efflux pump membrane protein ArsB -
GVI46_RS09650 1964556..1966712 + 2157 WP_063671350.1 type IA DNA topoisomerase -
GVI46_RS09655 1966782..1967375 + 594 WP_081252134.1 HNH endonuclease Toxin
GVI46_RS09660 1967381..1967809 + 429 WP_053487199.1 SMI1/KNR4 family protein Antitoxin
GVI46_RS09665 1968328..1969479 + 1152 WP_063671354.1 suppressor of fused domain protein -
GVI46_RS09670 1969927..1970961 + 1035 Protein_1832 topoisomerase C-terminal repeat-containing protein -
GVI46_RS09675 1971073..1971471 + 399 WP_055989387.1 PaaI family thioesterase -
GVI46_RS09680 1971476..1972105 - 630 WP_081252138.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Knr4/Smi1-like domain

(17-129)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 22935.80 Da        Isoelectric Point: 9.9369

>T147346 WP_081252134.1 NZ_CP047699:1966782-1967375 [Priestia megaterium]
INKDAKRYRNKETGQFTRGPNLVHEAGSGNVQPLEVPVVESVTVNKQNDSMKGTSVFDPDLVKAYLKDVESKTRLKVHKI
QVEFLKESLRNNKFEKLTPKETAKHRGRFTTSLKNKLIEEWEEKTNQKWPRYTEEVYDQSGEIARHIGQPYDAHHLIENN
FSGPHEWWNIHPAKYPDEHQQGIHGKGAPSRMLFPRR

Download         Length: 594 bp

>T147346 NZ_CP062910:c692131-690809 [Escherichia coli O112ab:H8]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 16637.67 Da        Isoelectric Point: 3.9200

>AT147346 WP_053487199.1 NZ_CP047699:1967381-1967809 [Priestia megaterium]
MADFKFINNGENKIYNLSEEEILKAEDRMGIRFPDDLRQLYLEVGYGFIKEPSNNAINRIMGPGTVANVKLREGVFEFDP
DLEELDEEDKLIFFEVNEGIYISLDLKLPNNPVFYFDTQIADSLEDFLKKFINDNEYYIDLE

Download         Length: 429 bp

>AT147346 NZ_CP062910:c692397-692131 [Escherichia coli O112ab:H8]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References